Ejection fraction response to exercise in patients with chest pain, coronary artery disease and normal resting ventricular function

Raymond J Gibbons, K. L. Lee, F. R. Cobb, R. E. Coleman, R. H. Jones

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

We studied the ejection fraction (EF) response to upright exercise using first-pass radionuclide angiography (RNA) in 281 patients with chest pain, significant coronary artery disease and normal resting ventricular function. A wide range of resting function (heart rate and EF) and exercise function (heart rate, EF and peak work load) was measured in this population. The EF response to exercise (ΔEF) varied widely, ranging from a decrease of 36% to an increase of 26%. Twenty-eight clinical, catheterization and RNA variables were examined to determine their relationship to ΔEF. Considered individually, the variables showing the strongest relationship were resting pulse pressure, positive exercise ECG changes and adequate exercise. Multivariable analysis identified resting pulse pressure, adequate exercise, resting EF, the change in end-diastolic volume index with exercise, positive exercise ECG changes and, to a lesser degree, the number of diseased vessels as variables that were significant independent predictors of ΔEF. These observations indicate that ΔEF is a complex response that is influenced by many pathophysiologic variables in the presence of coronary artery disease. Several of these variables are not related to the extent of coronay artery disease.

Original languageEnglish (US)
Pages (from-to)643-648
Number of pages6
JournalCirculation
Volume66
Issue number3
StatePublished - 1982
Externally publishedYes

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Ventricular Function
Chest Pain
Coronary Artery Disease
Exercise
Electrocardiography
First-Pass Ventriculography
Heart Rate
Radionuclide Angiography
Blood Pressure
Workload
Catheterization
Arteries

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Ejection fraction response to exercise in patients with chest pain, coronary artery disease and normal resting ventricular function. / Gibbons, Raymond J; Lee, K. L.; Cobb, F. R.; Coleman, R. E.; Jones, R. H.

In: Circulation, Vol. 66, No. 3, 1982, p. 643-648.

Research output: Contribution to journalArticle

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