Eight-year trend of acute respiratory distress syndrome: A population-based study in Olmsted County, Minnesota

Guangxi Li, Michael Malinchoc, Rodrigo Cartin-Ceba, Chakradhar V. Venkata, Daryl J Kor, Steve G. Peters, Rolf D. Hubmayr, Ognjen Gajic

Research output: Contribution to journalArticle

201 Citations (Scopus)

Abstract

Rationale: Significant progress has been made in understanding the pathogenesis of acute respiratory distress syndrome (ARDS). Recent advances in hospital practice may have reduced the incidence of this lethal syndrome. Objectives: To observe incidence trends and associated outcomes of ARDS. Methods: This population-based cohort study was conducted in Olmsted County, Minnesota. Using a validated screening protocol, investigators identified intensive care patients with acute hypoxemia and bilateral pulmonary infiltrates. The presence of ARDS was independently confirmed according to American-European Consensus Conference criteria. The incidence of ARDS and associated outcomes were comparedover the 8-year study period (2001-2008). Measurements and Main Results: Over the 8-year period, critically ill Olmsted County residents presented with increasing severity of acute illness, a greater number of comorbidities, and a higher prevalence of major predisposing conditions for ARDS. The ARDS incidence decreased significantly from 82.4 to 38.9 per 100,000 person-years during the study period (P<0.001). A decline in hospital-acquired ARDS (P<0.001) was responsible for the fall in the incidence density with no change on admission (P=0.877). Overall, mortality and hospital and intensive care unit lengths of stay decreased over time (P<0.001), whereas the ARDS case-fatality did not change significantly. Conclusions: Despite an increase in patients' severity of illness, number of comorbidities, and prevalence of major ARDS risk factors, the incidence of ARDS in this suburban community decreased by more than half. Correlation of the observed findingswith changes in health care delivery may have important implications for the planning of acute care services in other regions.

Original languageEnglish (US)
Pages (from-to)59-66
Number of pages8
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume183
Issue number1
DOIs
StatePublished - Jan 1 2011

Fingerprint

Adult Respiratory Distress Syndrome
Population
Incidence
Comorbidity
Critical Care
Hospital Mortality
Critical Illness
Intensive Care Units
Length of Stay
Cohort Studies
Research Personnel
Delivery of Health Care
Lung

Keywords

  • Acute respiratory distress syndrome
  • Epidemiology
  • Incidence

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

Cite this

Eight-year trend of acute respiratory distress syndrome : A population-based study in Olmsted County, Minnesota. / Li, Guangxi; Malinchoc, Michael; Cartin-Ceba, Rodrigo; Venkata, Chakradhar V.; Kor, Daryl J; Peters, Steve G.; Hubmayr, Rolf D.; Gajic, Ognjen.

In: American Journal of Respiratory and Critical Care Medicine, Vol. 183, No. 1, 01.01.2011, p. 59-66.

Research output: Contribution to journalArticle

Li, Guangxi ; Malinchoc, Michael ; Cartin-Ceba, Rodrigo ; Venkata, Chakradhar V. ; Kor, Daryl J ; Peters, Steve G. ; Hubmayr, Rolf D. ; Gajic, Ognjen. / Eight-year trend of acute respiratory distress syndrome : A population-based study in Olmsted County, Minnesota. In: American Journal of Respiratory and Critical Care Medicine. 2011 ; Vol. 183, No. 1. pp. 59-66.
@article{e84f9fb82ad54eda815af885a2632b29,
title = "Eight-year trend of acute respiratory distress syndrome: A population-based study in Olmsted County, Minnesota",
abstract = "Rationale: Significant progress has been made in understanding the pathogenesis of acute respiratory distress syndrome (ARDS). Recent advances in hospital practice may have reduced the incidence of this lethal syndrome. Objectives: To observe incidence trends and associated outcomes of ARDS. Methods: This population-based cohort study was conducted in Olmsted County, Minnesota. Using a validated screening protocol, investigators identified intensive care patients with acute hypoxemia and bilateral pulmonary infiltrates. The presence of ARDS was independently confirmed according to American-European Consensus Conference criteria. The incidence of ARDS and associated outcomes were comparedover the 8-year study period (2001-2008). Measurements and Main Results: Over the 8-year period, critically ill Olmsted County residents presented with increasing severity of acute illness, a greater number of comorbidities, and a higher prevalence of major predisposing conditions for ARDS. The ARDS incidence decreased significantly from 82.4 to 38.9 per 100,000 person-years during the study period (P<0.001). A decline in hospital-acquired ARDS (P<0.001) was responsible for the fall in the incidence density with no change on admission (P=0.877). Overall, mortality and hospital and intensive care unit lengths of stay decreased over time (P<0.001), whereas the ARDS case-fatality did not change significantly. Conclusions: Despite an increase in patients' severity of illness, number of comorbidities, and prevalence of major ARDS risk factors, the incidence of ARDS in this suburban community decreased by more than half. Correlation of the observed findingswith changes in health care delivery may have important implications for the planning of acute care services in other regions.",
keywords = "Acute respiratory distress syndrome, Epidemiology, Incidence",
author = "Guangxi Li and Michael Malinchoc and Rodrigo Cartin-Ceba and Venkata, {Chakradhar V.} and Kor, {Daryl J} and Peters, {Steve G.} and Hubmayr, {Rolf D.} and Ognjen Gajic",
year = "2011",
month = "1",
day = "1",
doi = "10.1164/rccm.201003-0436OC",
language = "English (US)",
volume = "183",
pages = "59--66",
journal = "American Journal of Respiratory and Critical Care Medicine",
issn = "1073-449X",
publisher = "American Thoracic Society",
number = "1",

}

TY - JOUR

T1 - Eight-year trend of acute respiratory distress syndrome

T2 - A population-based study in Olmsted County, Minnesota

AU - Li, Guangxi

AU - Malinchoc, Michael

AU - Cartin-Ceba, Rodrigo

AU - Venkata, Chakradhar V.

AU - Kor, Daryl J

AU - Peters, Steve G.

AU - Hubmayr, Rolf D.

AU - Gajic, Ognjen

PY - 2011/1/1

Y1 - 2011/1/1

N2 - Rationale: Significant progress has been made in understanding the pathogenesis of acute respiratory distress syndrome (ARDS). Recent advances in hospital practice may have reduced the incidence of this lethal syndrome. Objectives: To observe incidence trends and associated outcomes of ARDS. Methods: This population-based cohort study was conducted in Olmsted County, Minnesota. Using a validated screening protocol, investigators identified intensive care patients with acute hypoxemia and bilateral pulmonary infiltrates. The presence of ARDS was independently confirmed according to American-European Consensus Conference criteria. The incidence of ARDS and associated outcomes were comparedover the 8-year study period (2001-2008). Measurements and Main Results: Over the 8-year period, critically ill Olmsted County residents presented with increasing severity of acute illness, a greater number of comorbidities, and a higher prevalence of major predisposing conditions for ARDS. The ARDS incidence decreased significantly from 82.4 to 38.9 per 100,000 person-years during the study period (P<0.001). A decline in hospital-acquired ARDS (P<0.001) was responsible for the fall in the incidence density with no change on admission (P=0.877). Overall, mortality and hospital and intensive care unit lengths of stay decreased over time (P<0.001), whereas the ARDS case-fatality did not change significantly. Conclusions: Despite an increase in patients' severity of illness, number of comorbidities, and prevalence of major ARDS risk factors, the incidence of ARDS in this suburban community decreased by more than half. Correlation of the observed findingswith changes in health care delivery may have important implications for the planning of acute care services in other regions.

AB - Rationale: Significant progress has been made in understanding the pathogenesis of acute respiratory distress syndrome (ARDS). Recent advances in hospital practice may have reduced the incidence of this lethal syndrome. Objectives: To observe incidence trends and associated outcomes of ARDS. Methods: This population-based cohort study was conducted in Olmsted County, Minnesota. Using a validated screening protocol, investigators identified intensive care patients with acute hypoxemia and bilateral pulmonary infiltrates. The presence of ARDS was independently confirmed according to American-European Consensus Conference criteria. The incidence of ARDS and associated outcomes were comparedover the 8-year study period (2001-2008). Measurements and Main Results: Over the 8-year period, critically ill Olmsted County residents presented with increasing severity of acute illness, a greater number of comorbidities, and a higher prevalence of major predisposing conditions for ARDS. The ARDS incidence decreased significantly from 82.4 to 38.9 per 100,000 person-years during the study period (P<0.001). A decline in hospital-acquired ARDS (P<0.001) was responsible for the fall in the incidence density with no change on admission (P=0.877). Overall, mortality and hospital and intensive care unit lengths of stay decreased over time (P<0.001), whereas the ARDS case-fatality did not change significantly. Conclusions: Despite an increase in patients' severity of illness, number of comorbidities, and prevalence of major ARDS risk factors, the incidence of ARDS in this suburban community decreased by more than half. Correlation of the observed findingswith changes in health care delivery may have important implications for the planning of acute care services in other regions.

KW - Acute respiratory distress syndrome

KW - Epidemiology

KW - Incidence

UR - http://www.scopus.com/inward/record.url?scp=78650780266&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78650780266&partnerID=8YFLogxK

U2 - 10.1164/rccm.201003-0436OC

DO - 10.1164/rccm.201003-0436OC

M3 - Article

C2 - 20693377

AN - SCOPUS:78650780266

VL - 183

SP - 59

EP - 66

JO - American Journal of Respiratory and Critical Care Medicine

JF - American Journal of Respiratory and Critical Care Medicine

SN - 1073-449X

IS - 1

ER -