EGFR somatic mutations in lung tumors: Radon exposure and passive smoking in former- and never-smoking U.S. women

Masataka Taga; Leah E. Mechanic; Nobutoshi Hagiwara; Kirsi H. Vähäkangas; William P. Bennett; Michael C.R. Alavanja; Judith A. Welsh; Mohammed A. Khan; Adam Lee; Robert Diasio; Eric Edell; Aaron Bungum; Jin Sung Jang; Ping Yang; Jin Jen; Curtis C. Harris

doi:10.1158/1055-9965.EPI-12-0166

EGFR somatic mutations in lung tumors: Radon exposure and passive smoking in former- and never-smoking U.S. women

Masataka Taga, Leah E. Mechanic, Nobutoshi Hagiwara, Kirsi H. Vähäkangas, William P. Bennett, Michael C.R. Alavanja, Judith A. Welsh, Mohammed A. Khan, Adam Lee, Robert Diasio, Eric Edell, Aaron Bungum, Jin Sung Jang, Ping Yang, Jin Jen, Curtis C. Harris

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Abstract

Background: Patients with lung cancer with mutations in EGF receptor (EGFR) tyrosine kinase have improved prognosis whentreated with EGFR inhibitors.Wehypothesized that EGFR mutationsmaybe related to residential radon or passive tobacco smoke. Methods: This hypothesis was investigated by analyzing EGFR mutations in 70 lung tumors from a population of never and long-term former female smokers from Missouri with detailed exposure assessments. The relationship with passive smoking was also examined in never-smoking female lung cancer cases from the Mayo clinic. Results: Overall, the frequency ofEGFR mutation was 41% [95% confidence interval (CI), 32%-49%]. Neither radon nor passive-smoking exposure was consistently associated with EGFR mutations in lung tumors. Conclusions: The results suggest that EGFR mutations are common in female, never-smoking lung cancer cases from the United States, and EGFR mutations are unlikely due to exposure to radon or passive smoking.

Original language	English (US)
Pages (from-to)	988-992
Number of pages	5
Journal	Cancer Epidemiology Biomarkers and Prevention
Volume	21
Issue number	6
DOIs	https://doi.org/10.1158/1055-9965.EPI-12-0166
State	Published - Jun 2012

ASJC Scopus subject areas

Epidemiology
Oncology

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Taga, M., Mechanic, L. E., Hagiwara, N., Vähäkangas, K. H., Bennett, W. P., Alavanja, M. C. R., Welsh, J. A., Khan, M. A., Lee, A., Diasio, R., Edell, E., Bungum, A., Jang, J. S., Yang, P., Jen, J., & Harris, C. C. (2012). EGFR somatic mutations in lung tumors: Radon exposure and passive smoking in former- and never-smoking U.S. women. Cancer Epidemiology Biomarkers and Prevention, 21(6), 988-992. https://doi.org/10.1158/1055-9965.EPI-12-0166

Taga, M, Mechanic, LE, Hagiwara, N, Vähäkangas, KH, Bennett, WP, Alavanja, MCR, Welsh, JA, Khan, MA, Lee, A, Diasio, R, Edell, E, Bungum, A, Jang, JS, Yang, P, Jen, J & Harris, CC 2012, 'EGFR somatic mutations in lung tumors: Radon exposure and passive smoking in former- and never-smoking U.S. women', Cancer Epidemiology Biomarkers and Prevention, vol. 21, no. 6, pp. 988-992. https://doi.org/10.1158/1055-9965.EPI-12-0166

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abstract = "Background: Patients with lung cancer with mutations in EGF receptor (EGFR) tyrosine kinase have improved prognosis whentreated with EGFR inhibitors.Wehypothesized that EGFR mutationsmaybe related to residential radon or passive tobacco smoke. Methods: This hypothesis was investigated by analyzing EGFR mutations in 70 lung tumors from a population of never and long-term former female smokers from Missouri with detailed exposure assessments. The relationship with passive smoking was also examined in never-smoking female lung cancer cases from the Mayo clinic. Results: Overall, the frequency ofEGFR mutation was 41% [95% confidence interval (CI), 32%-49%]. Neither radon nor passive-smoking exposure was consistently associated with EGFR mutations in lung tumors. Conclusions: The results suggest that EGFR mutations are common in female, never-smoking lung cancer cases from the United States, and EGFR mutations are unlikely due to exposure to radon or passive smoking.",

author = "Masataka Taga and Mechanic, {Leah E.} and Nobutoshi Hagiwara and V{\"a}h{\"a}kangas, {Kirsi H.} and Bennett, {William P.} and Alavanja, {Michael C.R.} and Welsh, {Judith A.} and Khan, {Mohammed A.} and Adam Lee and Robert Diasio and Eric Edell and Aaron Bungum and Jang, {Jin Sung} and Ping Yang and Jin Jen and Harris, {Curtis C.}",

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doi = "10.1158/1055-9965.EPI-12-0166",

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AU - Taga, Masataka

AU - Mechanic, Leah E.

AU - Hagiwara, Nobutoshi

AU - Vähäkangas, Kirsi H.

AU - Bennett, William P.

AU - Alavanja, Michael C.R.

AU - Welsh, Judith A.

AU - Khan, Mohammed A.

AU - Lee, Adam

AU - Diasio, Robert

AU - Edell, Eric

AU - Bungum, Aaron

AU - Jang, Jin Sung

AU - Yang, Ping

AU - Jen, Jin

AU - Harris, Curtis C.

PY - 2012/6

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N2 - Background: Patients with lung cancer with mutations in EGF receptor (EGFR) tyrosine kinase have improved prognosis whentreated with EGFR inhibitors.Wehypothesized that EGFR mutationsmaybe related to residential radon or passive tobacco smoke. Methods: This hypothesis was investigated by analyzing EGFR mutations in 70 lung tumors from a population of never and long-term former female smokers from Missouri with detailed exposure assessments. The relationship with passive smoking was also examined in never-smoking female lung cancer cases from the Mayo clinic. Results: Overall, the frequency ofEGFR mutation was 41% [95% confidence interval (CI), 32%-49%]. Neither radon nor passive-smoking exposure was consistently associated with EGFR mutations in lung tumors. Conclusions: The results suggest that EGFR mutations are common in female, never-smoking lung cancer cases from the United States, and EGFR mutations are unlikely due to exposure to radon or passive smoking.

AB - Background: Patients with lung cancer with mutations in EGF receptor (EGFR) tyrosine kinase have improved prognosis whentreated with EGFR inhibitors.Wehypothesized that EGFR mutationsmaybe related to residential radon or passive tobacco smoke. Methods: This hypothesis was investigated by analyzing EGFR mutations in 70 lung tumors from a population of never and long-term former female smokers from Missouri with detailed exposure assessments. The relationship with passive smoking was also examined in never-smoking female lung cancer cases from the Mayo clinic. Results: Overall, the frequency ofEGFR mutation was 41% [95% confidence interval (CI), 32%-49%]. Neither radon nor passive-smoking exposure was consistently associated with EGFR mutations in lung tumors. Conclusions: The results suggest that EGFR mutations are common in female, never-smoking lung cancer cases from the United States, and EGFR mutations are unlikely due to exposure to radon or passive smoking.

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EGFR somatic mutations in lung tumors: Radon exposure and passive smoking in former- and never-smoking U.S. women

Abstract

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