EGFR somatic mutations in lung tumors: Radon exposure and passive smoking in former- and never-smoking U.S. women

Masataka Taga, Leah E. Mechanic, Nobutoshi Hagiwara, Kirsi H. Vähäkangas, William P. Bennett, Michael C R Alavanja, Judith A. Welsh, Mohammed A. Khan, Adam Lee, Robert B Diasio, Eric Edell, Aaron Bungum, Jin Sung Jang, Ping Yang, Jin Jen, Curtis C. Harris

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background: Patients with lung cancer with mutations in EGF receptor (EGFR) tyrosine kinase have improved prognosis whentreated with EGFR inhibitors.Wehypothesized that EGFR mutationsmaybe related to residential radon or passive tobacco smoke. Methods: This hypothesis was investigated by analyzing EGFR mutations in 70 lung tumors from a population of never and long-term former female smokers from Missouri with detailed exposure assessments. The relationship with passive smoking was also examined in never-smoking female lung cancer cases from the Mayo clinic. Results: Overall, the frequency ofEGFR mutation was 41% [95% confidence interval (CI), 32%-49%]. Neither radon nor passive-smoking exposure was consistently associated with EGFR mutations in lung tumors. Conclusions: The results suggest that EGFR mutations are common in female, never-smoking lung cancer cases from the United States, and EGFR mutations are unlikely due to exposure to radon or passive smoking.

Original languageEnglish (US)
Pages (from-to)988-992
Number of pages5
JournalCancer Epidemiology Biomarkers and Prevention
Volume21
Issue number6
DOIs
StatePublished - Jun 2012

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Radon
Tobacco Smoke Pollution
Epidermal Growth Factor Receptor
Smoking
Lung
Mutation
Neoplasms
Lung Neoplasms
Mutation Rate
Smoke
Protein-Tyrosine Kinases
Tobacco
Confidence Intervals
Population

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

Taga, M., Mechanic, L. E., Hagiwara, N., Vähäkangas, K. H., Bennett, W. P., Alavanja, M. C. R., ... Harris, C. C. (2012). EGFR somatic mutations in lung tumors: Radon exposure and passive smoking in former- and never-smoking U.S. women. Cancer Epidemiology Biomarkers and Prevention, 21(6), 988-992. https://doi.org/10.1158/1055-9965.EPI-12-0166

EGFR somatic mutations in lung tumors : Radon exposure and passive smoking in former- and never-smoking U.S. women. / Taga, Masataka; Mechanic, Leah E.; Hagiwara, Nobutoshi; Vähäkangas, Kirsi H.; Bennett, William P.; Alavanja, Michael C R; Welsh, Judith A.; Khan, Mohammed A.; Lee, Adam; Diasio, Robert B; Edell, Eric; Bungum, Aaron; Jang, Jin Sung; Yang, Ping; Jen, Jin; Harris, Curtis C.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 21, No. 6, 06.2012, p. 988-992.

Research output: Contribution to journalArticle

Taga, M, Mechanic, LE, Hagiwara, N, Vähäkangas, KH, Bennett, WP, Alavanja, MCR, Welsh, JA, Khan, MA, Lee, A, Diasio, RB, Edell, E, Bungum, A, Jang, JS, Yang, P, Jen, J & Harris, CC 2012, 'EGFR somatic mutations in lung tumors: Radon exposure and passive smoking in former- and never-smoking U.S. women', Cancer Epidemiology Biomarkers and Prevention, vol. 21, no. 6, pp. 988-992. https://doi.org/10.1158/1055-9965.EPI-12-0166
Taga, Masataka ; Mechanic, Leah E. ; Hagiwara, Nobutoshi ; Vähäkangas, Kirsi H. ; Bennett, William P. ; Alavanja, Michael C R ; Welsh, Judith A. ; Khan, Mohammed A. ; Lee, Adam ; Diasio, Robert B ; Edell, Eric ; Bungum, Aaron ; Jang, Jin Sung ; Yang, Ping ; Jen, Jin ; Harris, Curtis C. / EGFR somatic mutations in lung tumors : Radon exposure and passive smoking in former- and never-smoking U.S. women. In: Cancer Epidemiology Biomarkers and Prevention. 2012 ; Vol. 21, No. 6. pp. 988-992.
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AU - Vähäkangas, Kirsi H.

AU - Bennett, William P.

AU - Alavanja, Michael C R

AU - Welsh, Judith A.

AU - Khan, Mohammed A.

AU - Lee, Adam

AU - Diasio, Robert B

AU - Edell, Eric

AU - Bungum, Aaron

AU - Jang, Jin Sung

AU - Yang, Ping

AU - Jen, Jin

AU - Harris, Curtis C.

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AB - Background: Patients with lung cancer with mutations in EGF receptor (EGFR) tyrosine kinase have improved prognosis whentreated with EGFR inhibitors.Wehypothesized that EGFR mutationsmaybe related to residential radon or passive tobacco smoke. Methods: This hypothesis was investigated by analyzing EGFR mutations in 70 lung tumors from a population of never and long-term former female smokers from Missouri with detailed exposure assessments. The relationship with passive smoking was also examined in never-smoking female lung cancer cases from the Mayo clinic. Results: Overall, the frequency ofEGFR mutation was 41% [95% confidence interval (CI), 32%-49%]. Neither radon nor passive-smoking exposure was consistently associated with EGFR mutations in lung tumors. Conclusions: The results suggest that EGFR mutations are common in female, never-smoking lung cancer cases from the United States, and EGFR mutations are unlikely due to exposure to radon or passive smoking.

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