EGFR somatic mutations in lung tumors: Radon exposure and passive smoking in former- and never-smoking U.S. women

Masataka Taga, Leah E. Mechanic, Nobutoshi Hagiwara, Kirsi H. Vähäkangas, William P. Bennett, Michael C.R. Alavanja, Judith A. Welsh, Mohammed A. Khan, Adam Lee, Robert Diasio, Eric Edell, Aaron Bungum, Jin Sung Jang, Ping Yang, Jin Jen, Curtis C. Harris

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Background: Patients with lung cancer with mutations in EGF receptor (EGFR) tyrosine kinase have improved prognosis whentreated with EGFR inhibitors.Wehypothesized that EGFR mutationsmaybe related to residential radon or passive tobacco smoke. Methods: This hypothesis was investigated by analyzing EGFR mutations in 70 lung tumors from a population of never and long-term former female smokers from Missouri with detailed exposure assessments. The relationship with passive smoking was also examined in never-smoking female lung cancer cases from the Mayo clinic. Results: Overall, the frequency ofEGFR mutation was 41% [95% confidence interval (CI), 32%-49%]. Neither radon nor passive-smoking exposure was consistently associated with EGFR mutations in lung tumors. Conclusions: The results suggest that EGFR mutations are common in female, never-smoking lung cancer cases from the United States, and EGFR mutations are unlikely due to exposure to radon or passive smoking.

Original languageEnglish (US)
Pages (from-to)988-992
Number of pages5
JournalCancer Epidemiology Biomarkers and Prevention
Volume21
Issue number6
DOIs
StatePublished - Jun 2012

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Fingerprint Dive into the research topics of 'EGFR somatic mutations in lung tumors: Radon exposure and passive smoking in former- and never-smoking U.S. women'. Together they form a unique fingerprint.

  • Cite this

    Taga, M., Mechanic, L. E., Hagiwara, N., Vähäkangas, K. H., Bennett, W. P., Alavanja, M. C. R., Welsh, J. A., Khan, M. A., Lee, A., Diasio, R., Edell, E., Bungum, A., Jang, J. S., Yang, P., Jen, J., & Harris, C. C. (2012). EGFR somatic mutations in lung tumors: Radon exposure and passive smoking in former- and never-smoking U.S. women. Cancer Epidemiology Biomarkers and Prevention, 21(6), 988-992. https://doi.org/10.1158/1055-9965.EPI-12-0166