EGFR autocrine signaling in a compliant interstitial space

Mechanotransduction from the outside in

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Cells transduce mechanical forces into biochemical signals; traditionally these processes are thought to occur through direct effects on the cell membrane, the cytoskeleton, or specific transmembrane proteins. In multicellular tissues mechanical forces alter intercellular spacing through redistribution of interstitial fluid. Recent morphological and biochemical observations, bolstered by analytical modeling, support a new paradigm for mechanotransduction arising from constitutive growth factor shedding into a dynamically regulated interstitial volume.

Original languageEnglish (US)
Pages (from-to)996-997
Number of pages2
JournalCell Cycle
Volume3
Issue number8
StatePublished - Aug 2004
Externally publishedYes

Fingerprint

Autocrine Communication
Extracellular Fluid
Cell membranes
Cytoskeleton
Intercellular Signaling Peptides and Proteins
Cell Membrane
Tissue
Fluids
Proteins

Keywords

  • Airway epithelium
  • Asthma
  • Compressive stress
  • HB-EGF
  • Lateral intercellular space
  • Shedding

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

EGFR autocrine signaling in a compliant interstitial space : Mechanotransduction from the outside in. / Tschumperlin, Daniel J.

In: Cell Cycle, Vol. 3, No. 8, 08.2004, p. 996-997.

Research output: Contribution to journalArticle

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