Efflux Limits Tumor Drug Delivery Despite Disrupted BBB

Jessica I. Griffith, Jann N. Sarkaria, William F. Elmquist

Research output: Contribution to journalShort surveypeer-review

Abstract

Apparent blood–brain barrier (BBB) disruption is common in glioblastoma (GBM), but has not translated to improved drug delivery efficacy. Recently, de Gooijer et al. demonstrated that efflux transporters can have a prominent role in limiting drug delivery. These transport systems contribute to ineffective drug delivery to tumor cells in the brain.

Original languageEnglish (US)
JournalTrends in Pharmacological Sciences
DOIs
StateAccepted/In press - 2021

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

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