Efficacy of lenalidomide in patients with chronic lymphocytic leukemia with high-risk cytogenetics

Taimur Sher; Kena C. Miller; David Lawrence; Amy Whitworth; Francisco Hernandez-Ilizaliturri; Myron S. Czuczman; Austin Miller; William Lawrence; Syed Ali Bilgrami; Raman Sood; Margaret T. Wood; Annemarie W. Block; Kelvin Lee; Asher Alban Chanan-Khan

doi:10.3109/10428190903406806

Efficacy of lenalidomide in patients with chronic lymphocytic leukemia with high-risk cytogenetics

Taimur Sher, Kena C. Miller, David Lawrence, Amy Whitworth, Francisco Hernandez-Ilizaliturri, Myron S. Czuczman, Austin Miller, William Lawrence, Syed Ali Bilgrami, Raman Sood, Margaret T. Wood, Annemarie W. Block, Kelvin Lee, Asher Alban Chanan-Khan

Hematology / Oncology / Cancer Center / Breast Clinic

Research output: Contribution to journal › Article › peer-review

77 Scopus citations

Abstract

Patients with chronic lymphocytic lymphoma (CLL) with high-risk cytogenetics [del(11q)(q22.3) or del(17p)(p13.1)] have limited therapeutic options and their prognosis remains poor. This analysis was conducted to determine the clinical activity of lenalidomide in patients with high-risk disease. Relapsed/refractory patients with CLL enrolled in a phase II clinical trial who had del(11q)(q22.3) or del(17p)(p13.1) were included in this analysis. Patients received single agent lenalidomide for 21 days of the 4 week treatment cycle. The overall response rate among patients with high-risk cytogenetics was 38%, with 19% of patients achieving a complete response. Median progression-free survival was 12.1 months, which is higher than emonstrated with other agents in comparable patient populations. In addition, the estimated 2-year survival probability was 58%, demonstrating that the responses achieved with lenalidomide are durable, even in patients with CLL with high-risk disease with poor risk cytogenetics.

Original language	English (US)
Pages (from-to)	85-88
Number of pages	4
Journal	Leukemia and Lymphoma
Volume	51
Issue number	1
DOIs	https://doi.org/10.3109/10428190903406806
State	Published - Jan 2010

Keywords

Chronic lymphocytic leukemia
Fludarabine-refractory
High-risk cytogenetics
Lenalidomide

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

Access to Document

10.3109/10428190903406806

Cite this

Sher, T., Miller, K. C., Lawrence, D., Whitworth, A., Hernandez-Ilizaliturri, F., Czuczman, M. S., Miller, A., Lawrence, W., Bilgrami, S. A., Sood, R., Wood, M. T., Block, A. W., Lee, K., & Chanan-Khan, A. A. (2010). Efficacy of lenalidomide in patients with chronic lymphocytic leukemia with high-risk cytogenetics. Leukemia and Lymphoma, 51(1), 85-88. https://doi.org/10.3109/10428190903406806

Efficacy of lenalidomide in patients with chronic lymphocytic leukemia with high-risk cytogenetics. / Sher, Taimur; Miller, Kena C.; Lawrence, David; Whitworth, Amy; Hernandez-Ilizaliturri, Francisco; Czuczman, Myron S.; Miller, Austin; Lawrence, William; Bilgrami, Syed Ali; Sood, Raman; Wood, Margaret T.; Block, Annemarie W.; Lee, Kelvin; Chanan-Khan, Asher Alban.

In: Leukemia and Lymphoma, Vol. 51, No. 1, 01.2010, p. 85-88.

Research output: Contribution to journal › Article › peer-review

Sher, T, Miller, KC, Lawrence, D, Whitworth, A, Hernandez-Ilizaliturri, F, Czuczman, MS, Miller, A, Lawrence, W, Bilgrami, SA, Sood, R, Wood, MT, Block, AW, Lee, K & Chanan-Khan, AA 2010, 'Efficacy of lenalidomide in patients with chronic lymphocytic leukemia with high-risk cytogenetics', Leukemia and Lymphoma, vol. 51, no. 1, pp. 85-88. https://doi.org/10.3109/10428190903406806

Sher, Taimur ; Miller, Kena C. ; Lawrence, David ; Whitworth, Amy ; Hernandez-Ilizaliturri, Francisco ; Czuczman, Myron S. ; Miller, Austin ; Lawrence, William ; Bilgrami, Syed Ali ; Sood, Raman ; Wood, Margaret T. ; Block, Annemarie W. ; Lee, Kelvin ; Chanan-Khan, Asher Alban. / Efficacy of lenalidomide in patients with chronic lymphocytic leukemia with high-risk cytogenetics. In: Leukemia and Lymphoma. 2010 ; Vol. 51, No. 1. pp. 85-88.

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abstract = "Patients with chronic lymphocytic lymphoma (CLL) with high-risk cytogenetics [del(11q)(q22.3) or del(17p)(p13.1)] have limited therapeutic options and their prognosis remains poor. This analysis was conducted to determine the clinical activity of lenalidomide in patients with high-risk disease. Relapsed/refractory patients with CLL enrolled in a phase II clinical trial who had del(11q)(q22.3) or del(17p)(p13.1) were included in this analysis. Patients received single agent lenalidomide for 21 days of the 4 week treatment cycle. The overall response rate among patients with high-risk cytogenetics was 38%, with 19% of patients achieving a complete response. Median progression-free survival was 12.1 months, which is higher than emonstrated with other agents in comparable patient populations. In addition, the estimated 2-year survival probability was 58%, demonstrating that the responses achieved with lenalidomide are durable, even in patients with CLL with high-risk disease with poor risk cytogenetics.",

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AU - Lawrence, William

AU - Bilgrami, Syed Ali

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AU - Wood, Margaret T.

AU - Block, Annemarie W.

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N2 - Patients with chronic lymphocytic lymphoma (CLL) with high-risk cytogenetics [del(11q)(q22.3) or del(17p)(p13.1)] have limited therapeutic options and their prognosis remains poor. This analysis was conducted to determine the clinical activity of lenalidomide in patients with high-risk disease. Relapsed/refractory patients with CLL enrolled in a phase II clinical trial who had del(11q)(q22.3) or del(17p)(p13.1) were included in this analysis. Patients received single agent lenalidomide for 21 days of the 4 week treatment cycle. The overall response rate among patients with high-risk cytogenetics was 38%, with 19% of patients achieving a complete response. Median progression-free survival was 12.1 months, which is higher than emonstrated with other agents in comparable patient populations. In addition, the estimated 2-year survival probability was 58%, demonstrating that the responses achieved with lenalidomide are durable, even in patients with CLL with high-risk disease with poor risk cytogenetics.

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Efficacy of lenalidomide in patients with chronic lymphocytic leukemia with high-risk cytogenetics

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