Abstract
Patients with chronic lymphocytic lymphoma (CLL) with high-risk cytogenetics [del(11q)(q22.3) or del(17p)(p13.1)] have limited therapeutic options and their prognosis remains poor. This analysis was conducted to determine the clinical activity of lenalidomide in patients with high-risk disease. Relapsed/refractory patients with CLL enrolled in a phase II clinical trial who had del(11q)(q22.3) or del(17p)(p13.1) were included in this analysis. Patients received single agent lenalidomide for 21 days of the 4 week treatment cycle. The overall response rate among patients with high-risk cytogenetics was 38%, with 19% of patients achieving a complete response. Median progression-free survival was 12.1 months, which is higher than emonstrated with other agents in comparable patient populations. In addition, the estimated 2-year survival probability was 58%, demonstrating that the responses achieved with lenalidomide are durable, even in patients with CLL with high-risk disease with poor risk cytogenetics.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 85-88 |
| Number of pages | 4 |
| Journal | Leukemia and Lymphoma |
| Volume | 51 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2010 |
| Externally published | Yes |
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Keywords
- Chronic lymphocytic leukemia
- Fludarabine-refractory
- High-risk cytogenetics
- Lenalidomide
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research
Cite this
Efficacy of lenalidomide in patients with chronic lymphocytic leukemia with high-risk cytogenetics. / Sher, Taimur; Miller, Kena C.; Lawrence, David; Whitworth, Amy; Hernandez-Ilizaliturri, Francisco; Czuczman, Myron S.; Miller, Austin; Lawrence, William; Bilgrami, Syed Ali; Sood, Raman; Wood, Margaret T.; Block, Annemarie W.; Lee, Kelvin; Chanan Khan, Asher A.
In: Leukemia and Lymphoma, Vol. 51, No. 1, 01.2010, p. 85-88.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Efficacy of lenalidomide in patients with chronic lymphocytic leukemia with high-risk cytogenetics
AU - Sher, Taimur
AU - Miller, Kena C.
AU - Lawrence, David
AU - Whitworth, Amy
AU - Hernandez-Ilizaliturri, Francisco
AU - Czuczman, Myron S.
AU - Miller, Austin
AU - Lawrence, William
AU - Bilgrami, Syed Ali
AU - Sood, Raman
AU - Wood, Margaret T.
AU - Block, Annemarie W.
AU - Lee, Kelvin
AU - Chanan Khan, Asher A
PY - 2010/1
Y1 - 2010/1
N2 - Patients with chronic lymphocytic lymphoma (CLL) with high-risk cytogenetics [del(11q)(q22.3) or del(17p)(p13.1)] have limited therapeutic options and their prognosis remains poor. This analysis was conducted to determine the clinical activity of lenalidomide in patients with high-risk disease. Relapsed/refractory patients with CLL enrolled in a phase II clinical trial who had del(11q)(q22.3) or del(17p)(p13.1) were included in this analysis. Patients received single agent lenalidomide for 21 days of the 4 week treatment cycle. The overall response rate among patients with high-risk cytogenetics was 38%, with 19% of patients achieving a complete response. Median progression-free survival was 12.1 months, which is higher than emonstrated with other agents in comparable patient populations. In addition, the estimated 2-year survival probability was 58%, demonstrating that the responses achieved with lenalidomide are durable, even in patients with CLL with high-risk disease with poor risk cytogenetics.
AB - Patients with chronic lymphocytic lymphoma (CLL) with high-risk cytogenetics [del(11q)(q22.3) or del(17p)(p13.1)] have limited therapeutic options and their prognosis remains poor. This analysis was conducted to determine the clinical activity of lenalidomide in patients with high-risk disease. Relapsed/refractory patients with CLL enrolled in a phase II clinical trial who had del(11q)(q22.3) or del(17p)(p13.1) were included in this analysis. Patients received single agent lenalidomide for 21 days of the 4 week treatment cycle. The overall response rate among patients with high-risk cytogenetics was 38%, with 19% of patients achieving a complete response. Median progression-free survival was 12.1 months, which is higher than emonstrated with other agents in comparable patient populations. In addition, the estimated 2-year survival probability was 58%, demonstrating that the responses achieved with lenalidomide are durable, even in patients with CLL with high-risk disease with poor risk cytogenetics.
KW - Chronic lymphocytic leukemia
KW - Fludarabine-refractory
KW - High-risk cytogenetics
KW - Lenalidomide
UR - http://www.scopus.com/inward/record.url?scp=74949083498&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=74949083498&partnerID=8YFLogxK
U2 - 10.3109/10428190903406806
DO - 10.3109/10428190903406806
M3 - Article
C2 - 20055660
AN - SCOPUS:74949083498
VL - 51
SP - 85
EP - 88
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
SN - 1042-8194
IS - 1
ER -