TY - JOUR
T1 - Efficacy of caspofungin in neutropenic and corticosteroid-immunosuppressed murine models of invasive pulmonary mucormycosis
AU - Lewis, Russell E.
AU - Leventakos, Konstantinos
AU - Liao, Guangling
AU - Kontoyiannis, Dimitrios P.
PY - 2011/7
Y1 - 2011/7
N2 - Caspofungin (CFG) was tested in neutropenic and corticosteroid- immunosuppressed mice challenged with a lethal sinopulmonary inoculum of Rhizopus oryzae. Compared to untreated controls, CFG administered at 1 mg/kg of body weight/day significantly improved survival (54% versus 19%; P = 0.003) and reduced median R. oryzae fungal burden by 1.5 log10 for conidial equivalent DNA in neutropenic but not corticosteroid-immunosuppressed animals. CFG administered at 16 mg/kg/day was not significantly better than a saline control for treatment of invasive pulmonary mucormycosis (IPM) in either neutropenic or corticosteroid-immunosuppressed animals.
AB - Caspofungin (CFG) was tested in neutropenic and corticosteroid- immunosuppressed mice challenged with a lethal sinopulmonary inoculum of Rhizopus oryzae. Compared to untreated controls, CFG administered at 1 mg/kg of body weight/day significantly improved survival (54% versus 19%; P = 0.003) and reduced median R. oryzae fungal burden by 1.5 log10 for conidial equivalent DNA in neutropenic but not corticosteroid-immunosuppressed animals. CFG administered at 16 mg/kg/day was not significantly better than a saline control for treatment of invasive pulmonary mucormycosis (IPM) in either neutropenic or corticosteroid-immunosuppressed animals.
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U2 - 10.1128/AAC.01812-10
DO - 10.1128/AAC.01812-10
M3 - Article
C2 - 21537029
AN - SCOPUS:79959198616
SN - 0066-4804
VL - 55
SP - 3584
EP - 3587
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 7
ER -