Efficacy of caspofungin in neutropenic and corticosteroid-immunosuppressed murine models of invasive pulmonary mucormycosis

Russell E. Lewis, Konstantinos Leventakos, Guangling Liao, Dimitrios P. Kontoyiannis

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Caspofungin (CFG) was tested in neutropenic and corticosteroid- immunosuppressed mice challenged with a lethal sinopulmonary inoculum of Rhizopus oryzae. Compared to untreated controls, CFG administered at 1 mg/kg of body weight/day significantly improved survival (54% versus 19%; P = 0.003) and reduced median R. oryzae fungal burden by 1.5 log10 for conidial equivalent DNA in neutropenic but not corticosteroid-immunosuppressed animals. CFG administered at 16 mg/kg/day was not significantly better than a saline control for treatment of invasive pulmonary mucormycosis (IPM) in either neutropenic or corticosteroid-immunosuppressed animals.

Original languageEnglish (US)
Pages (from-to)3584-3587
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume55
Issue number7
DOIs
StatePublished - Jul 2011

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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