Efficacy of bortezomib as first-line treatment for patients with multiple myeloma

Utkarsh Painuly, Shaji Kumar

Research output: Contribution to journalReview article

16 Scopus citations

Abstract

Recent years have seen a dramatic change in the approach towards diagnosing and treating Multiple Myeloma. Newer and more target specific approach to treatment has prolonged the survival for patients with multiple myeloma. The proteasome inhibitors make an important class of anti-myeloma drugs that disrupts the proteolytic machinery of the tumor cells preferentially, enhancing their susceptibility to apoptosis. Bortezomib, in particular has shown significant clinical efficacy in myeloma treatment. It is the most commonly used proteasome inhibitor and has been tested to be effective in prolonging the overall survival in several trials. Its combinations with cyclophosphamide and dexamethasone are the treatment of choice for standard risk patients following the mSMART guidelines. The success with its lower dosage in elderly and its proven efficacious subcutaneous usage makes Bortezomib a useful agent for maximizing patient compliance and minimizing therapy related toxicity and costs. This review discusses several trials where Bortezomib has been used as a single/combination agent for front-line treatment of multiple myeloma.

Original languageEnglish (US)
Pages (from-to)53-73
Number of pages21
JournalClinical Medicine Insights: Oncology
Volume7
DOIs
StatePublished - 2012

Keywords

  • Bortezomib
  • Clinical outcomes
  • Efficacy
  • First-line
  • Multiple myeloma

ASJC Scopus subject areas

  • Oncology

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