Efficacy of beclomethasone nasal solution, flunisolide, and cromolyn in relieving symptoms of ragweed allergy

P. W. Welsh, W. E. Stricker, C. P. Chu, James M Naessens, M. E. Reese, C. E. Reed, J. P. Marcoux

Research output: Contribution to journalArticle

228 Citations (Scopus)

Abstract

Although three effective topical treatments for allergic rhinitis are available, little information to assist the clinician in choosing among them has been reported. Therefore, we conducted a randomized clinical trial to compare beclomethasone nasal solution, flunisolide, and cromolyn with placebo in 120 patients with hay fever during the ragweed season of 1984. We found that all three agents were superior to placebo (P < 0.001) and that the glucocorticoids were more effective than cromolyn (P < 0.001). Surprisingly, we also found that these intranasal treatments considerably reduced the symptoms of seasonal asthma. Further study of this therapeutic advantage is needed.

Original languageEnglish (US)
Pages (from-to)125-134
Number of pages10
JournalMayo Clinic Proceedings
Volume62
Issue number2
StatePublished - 1987
Externally publishedYes

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flunisolide
Ambrosia
Beclomethasone
Cromolyn Sodium
Nose
Hypersensitivity
Placebos
Seasonal Allergic Rhinitis
Glucocorticoids
Therapeutics
Asthma
Randomized Controlled Trials

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Welsh, P. W., Stricker, W. E., Chu, C. P., Naessens, J. M., Reese, M. E., Reed, C. E., & Marcoux, J. P. (1987). Efficacy of beclomethasone nasal solution, flunisolide, and cromolyn in relieving symptoms of ragweed allergy. Mayo Clinic Proceedings, 62(2), 125-134.

Efficacy of beclomethasone nasal solution, flunisolide, and cromolyn in relieving symptoms of ragweed allergy. / Welsh, P. W.; Stricker, W. E.; Chu, C. P.; Naessens, James M; Reese, M. E.; Reed, C. E.; Marcoux, J. P.

In: Mayo Clinic Proceedings, Vol. 62, No. 2, 1987, p. 125-134.

Research output: Contribution to journalArticle

Welsh, PW, Stricker, WE, Chu, CP, Naessens, JM, Reese, ME, Reed, CE & Marcoux, JP 1987, 'Efficacy of beclomethasone nasal solution, flunisolide, and cromolyn in relieving symptoms of ragweed allergy', Mayo Clinic Proceedings, vol. 62, no. 2, pp. 125-134.
Welsh, P. W. ; Stricker, W. E. ; Chu, C. P. ; Naessens, James M ; Reese, M. E. ; Reed, C. E. ; Marcoux, J. P. / Efficacy of beclomethasone nasal solution, flunisolide, and cromolyn in relieving symptoms of ragweed allergy. In: Mayo Clinic Proceedings. 1987 ; Vol. 62, No. 2. pp. 125-134.
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