Efficacy and treatment-related toxicity of radiotherapy for early-stage primary non-Hodgkin lymphoma of the parotid gland

Kenneth R. Olivier, Paul D. Brown, Scott L. Stafford, Stephen Maxted Ansell, James A. Martenson

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

To assess the efficacy of radiotherapy (RT) in the treatment of primary non-Hodgkin lymphoma (NHL) of the parotid gland. Data on 35 consecutive patients seen at Mayo Clinic between 1974 and 2000 with Ann Arbor Stage I and II NHL of the parotid gland were reviewed retrospectively. Radiotherapy was given to 23 patients, and 12 patients were observed. Eight patients received RT to local fields only. In addition to local fields, 9 patients received ipsilateral neck irradiation, and 6 patients received both ipsilateral and contralateral neck irradiation. Median follow-up was 6.5 years (range, 2 months-24 years). Local control was significantly improved in the RT group compared with the observation group (p = 0.03). Both overall survival and disease-specific survival were 90% at 5 years and 71% at 10 years. There was no significant difference in disease-specific survival or overall survival between the RT and observation groups. The overall prognosis for this rare presentation of NHL is excellent. Radiotherapy provided significant improvement in local control with minimal morbidity and should be considered in the treatment of these patients.

Original languageEnglish (US)
Pages (from-to)1510-1514
Number of pages5
JournalInternational Journal of Radiation Oncology Biology Physics
Volume60
Issue number5
DOIs
StatePublished - Dec 1 2004

Fingerprint

salivary glands
Parotid Gland
toxicity
Non-Hodgkin's Lymphoma
radiation therapy
Radiotherapy
Survival
Neck
Observation
irradiation
prognosis
Morbidity
Therapeutics

Keywords

  • Lymphoma
  • Parotid gland
  • Radiotherapy

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation

Cite this

Efficacy and treatment-related toxicity of radiotherapy for early-stage primary non-Hodgkin lymphoma of the parotid gland. / Olivier, Kenneth R.; Brown, Paul D.; Stafford, Scott L.; Ansell, Stephen Maxted; Martenson, James A.

In: International Journal of Radiation Oncology Biology Physics, Vol. 60, No. 5, 01.12.2004, p. 1510-1514.

Research output: Contribution to journalArticle

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