Efficacy and safety of ab interno trabeculectomy in juvenile open-angle glaucoma

Sourabh Arora, Masahiro Maeda, Brian Francis, Mariko Maeda, Arthur J Sit, Sameh Mosaed, Samir Nazarali, Karim F. Damji

Research output: Contribution to journalArticle

Abstract

Objective: To determine the efficacy and safety of ab interno trabeculectomy with Trabectome in juvenile open-angle glaucoma (JOAG) patients. Design: Prospective cohort study. Methods: Evaluation of the 12-month results of 2 patient groups receiving ab interno trabeculectomy: group 1, eyes with no prior incisional surgery; group 2, eyes that had prior incisional cataract or glaucoma surgery. Results: Group 1, 40 eyes (average age 31 ± 7 years), had a significant reduction in intraocular pressure (IOP) of 10.6 mm Hg at 12 months from a baseline of 27.4 mm Hg (p = 0.01), and the number of glaucoma medications reduced by 0.4 (p = 0.80). Four eyes (10%) within the study period required a secondary glaucoma surgery. Group 2, 20 eyes (average age 27 ± 8 years), had a significant reduction in IOP of 8.8 mm Hg from a baseline of 27.1 mm Hg (p = 0.06), and the number of glaucoma medications reduced by 1.4 (p = 0.36). Five eyes (25%) from this group underwent a secondary glaucoma surgery within 12 months. Conclusion: After 1 year of follow-up, ab interno trabeculectomy appears to be an effective and safe intervention for patients with JOAG; however, a reduction in use of topical medications may not be observed in those receiving ab interno trabeculectomy as a primary procedure.

Original languageEnglish (US)
JournalCanadian Journal of Ophthalmology
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Trabeculectomy
Open Angle Glaucoma
Glaucoma
Safety
Intraocular Pressure
Cataract
Cohort Studies
Prospective Studies

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Efficacy and safety of ab interno trabeculectomy in juvenile open-angle glaucoma. / Arora, Sourabh; Maeda, Masahiro; Francis, Brian; Maeda, Mariko; Sit, Arthur J; Mosaed, Sameh; Nazarali, Samir; Damji, Karim F.

In: Canadian Journal of Ophthalmology, 01.01.2018.

Research output: Contribution to journalArticle

Arora, Sourabh ; Maeda, Masahiro ; Francis, Brian ; Maeda, Mariko ; Sit, Arthur J ; Mosaed, Sameh ; Nazarali, Samir ; Damji, Karim F. / Efficacy and safety of ab interno trabeculectomy in juvenile open-angle glaucoma. In: Canadian Journal of Ophthalmology. 2018.
@article{a352878da0274a54b2fb432239197f04,
title = "Efficacy and safety of ab interno trabeculectomy in juvenile open-angle glaucoma",
abstract = "Objective: To determine the efficacy and safety of ab interno trabeculectomy with Trabectome in juvenile open-angle glaucoma (JOAG) patients. Design: Prospective cohort study. Methods: Evaluation of the 12-month results of 2 patient groups receiving ab interno trabeculectomy: group 1, eyes with no prior incisional surgery; group 2, eyes that had prior incisional cataract or glaucoma surgery. Results: Group 1, 40 eyes (average age 31 ± 7 years), had a significant reduction in intraocular pressure (IOP) of 10.6 mm Hg at 12 months from a baseline of 27.4 mm Hg (p = 0.01), and the number of glaucoma medications reduced by 0.4 (p = 0.80). Four eyes (10{\%}) within the study period required a secondary glaucoma surgery. Group 2, 20 eyes (average age 27 ± 8 years), had a significant reduction in IOP of 8.8 mm Hg from a baseline of 27.1 mm Hg (p = 0.06), and the number of glaucoma medications reduced by 1.4 (p = 0.36). Five eyes (25{\%}) from this group underwent a secondary glaucoma surgery within 12 months. Conclusion: After 1 year of follow-up, ab interno trabeculectomy appears to be an effective and safe intervention for patients with JOAG; however, a reduction in use of topical medications may not be observed in those receiving ab interno trabeculectomy as a primary procedure.",
author = "Sourabh Arora and Masahiro Maeda and Brian Francis and Mariko Maeda and Sit, {Arthur J} and Sameh Mosaed and Samir Nazarali and Damji, {Karim F.}",
year = "2018",
month = "1",
day = "1",
doi = "10.1016/j.jcjo.2017.12.013",
language = "English (US)",
journal = "Canadian Journal of Ophthalmology",
issn = "0008-4182",
publisher = "Canadian Ophthalmological Society",

}

TY - JOUR

T1 - Efficacy and safety of ab interno trabeculectomy in juvenile open-angle glaucoma

AU - Arora, Sourabh

AU - Maeda, Masahiro

AU - Francis, Brian

AU - Maeda, Mariko

AU - Sit, Arthur J

AU - Mosaed, Sameh

AU - Nazarali, Samir

AU - Damji, Karim F.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Objective: To determine the efficacy and safety of ab interno trabeculectomy with Trabectome in juvenile open-angle glaucoma (JOAG) patients. Design: Prospective cohort study. Methods: Evaluation of the 12-month results of 2 patient groups receiving ab interno trabeculectomy: group 1, eyes with no prior incisional surgery; group 2, eyes that had prior incisional cataract or glaucoma surgery. Results: Group 1, 40 eyes (average age 31 ± 7 years), had a significant reduction in intraocular pressure (IOP) of 10.6 mm Hg at 12 months from a baseline of 27.4 mm Hg (p = 0.01), and the number of glaucoma medications reduced by 0.4 (p = 0.80). Four eyes (10%) within the study period required a secondary glaucoma surgery. Group 2, 20 eyes (average age 27 ± 8 years), had a significant reduction in IOP of 8.8 mm Hg from a baseline of 27.1 mm Hg (p = 0.06), and the number of glaucoma medications reduced by 1.4 (p = 0.36). Five eyes (25%) from this group underwent a secondary glaucoma surgery within 12 months. Conclusion: After 1 year of follow-up, ab interno trabeculectomy appears to be an effective and safe intervention for patients with JOAG; however, a reduction in use of topical medications may not be observed in those receiving ab interno trabeculectomy as a primary procedure.

AB - Objective: To determine the efficacy and safety of ab interno trabeculectomy with Trabectome in juvenile open-angle glaucoma (JOAG) patients. Design: Prospective cohort study. Methods: Evaluation of the 12-month results of 2 patient groups receiving ab interno trabeculectomy: group 1, eyes with no prior incisional surgery; group 2, eyes that had prior incisional cataract or glaucoma surgery. Results: Group 1, 40 eyes (average age 31 ± 7 years), had a significant reduction in intraocular pressure (IOP) of 10.6 mm Hg at 12 months from a baseline of 27.4 mm Hg (p = 0.01), and the number of glaucoma medications reduced by 0.4 (p = 0.80). Four eyes (10%) within the study period required a secondary glaucoma surgery. Group 2, 20 eyes (average age 27 ± 8 years), had a significant reduction in IOP of 8.8 mm Hg from a baseline of 27.1 mm Hg (p = 0.06), and the number of glaucoma medications reduced by 1.4 (p = 0.36). Five eyes (25%) from this group underwent a secondary glaucoma surgery within 12 months. Conclusion: After 1 year of follow-up, ab interno trabeculectomy appears to be an effective and safe intervention for patients with JOAG; however, a reduction in use of topical medications may not be observed in those receiving ab interno trabeculectomy as a primary procedure.

UR - http://www.scopus.com/inward/record.url?scp=85043514768&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85043514768&partnerID=8YFLogxK

U2 - 10.1016/j.jcjo.2017.12.013

DO - 10.1016/j.jcjo.2017.12.013

M3 - Article

JO - Canadian Journal of Ophthalmology

JF - Canadian Journal of Ophthalmology

SN - 0008-4182

ER -