TY - JOUR
T1 - Effects of weight loss on insulin sensitivity and arterial stiffness in overweight adults
AU - Dengel, Donald R.
AU - Kelly, Aaron S.
AU - Olson, Thomas P.
AU - Kaiser, Daniel R.
AU - Dengel, Jana L.
AU - Bank, Alan J.
N1 - Funding Information:
This study was supported in part by the Department of Veterans Affairs VA Merit Award (to DRD) and the General Clinical Research Center Program, NCRR/NIH (GCRC: M01-RR00400).
PY - 2006/7
Y1 - 2006/7
N2 - Obesity is characterized by metabolic and vascular abnormalities. We examined the effects of weight loss on insulin sensitivity and arterial stiffness in overweight adults. Twelve (9 females; 3 males) overweight (body mass index, 30.3 ± 3.7) adults (54.9 ± 3.9 years) without diabetes or vascular disease were counseled by a registered dietician to lose weight over 6 months. Vascular structure, function, and wall mechanical properties were measured via ultrasound. Intravenous glucose tolerance test, 24-hour blood pressure, body composition (dual-energy x-ray absorptiometry), and lipids were also assessed. There were significant reductions in body mass (86.3 ± 14.2 vs 79.5 ± 13.8 kg, P < .0001) and percentage of fat (44.3% ± 7.0% vs 41.0% ± 8.5%, P < .01) after weight loss. There were significant improvements in total cholesterol (6.0 ± 0.9 vs 5.0 ± 0.8 mmol/L, P < .0001), low-density lipoprotein cholesterol (3.9 ± 0.7 vs 3.2 ± 0.6 mmol/L, P < .0001), triglycerides (3.4 ± 2.3 vs 2.4 ± 0.9 mmol/L, P < .05), and insulin sensitivity (3.3 ± 1.7 vs 5.4 ± 1.6 μU × 10-4 min-1 mL-1, P < .0001) after weight loss. Brachial artery compliance (P < .05) and distensibility (P < .05) curves over the physiologic pressure range improved, whereas endothelial function and intima-media thickness remained unchanged. In overweight adults, 6 months of weight loss resulted in improvements in body composition, insulin sensitivity, lipid profile, and brachial artery compliance and distensibility.
AB - Obesity is characterized by metabolic and vascular abnormalities. We examined the effects of weight loss on insulin sensitivity and arterial stiffness in overweight adults. Twelve (9 females; 3 males) overweight (body mass index, 30.3 ± 3.7) adults (54.9 ± 3.9 years) without diabetes or vascular disease were counseled by a registered dietician to lose weight over 6 months. Vascular structure, function, and wall mechanical properties were measured via ultrasound. Intravenous glucose tolerance test, 24-hour blood pressure, body composition (dual-energy x-ray absorptiometry), and lipids were also assessed. There were significant reductions in body mass (86.3 ± 14.2 vs 79.5 ± 13.8 kg, P < .0001) and percentage of fat (44.3% ± 7.0% vs 41.0% ± 8.5%, P < .01) after weight loss. There were significant improvements in total cholesterol (6.0 ± 0.9 vs 5.0 ± 0.8 mmol/L, P < .0001), low-density lipoprotein cholesterol (3.9 ± 0.7 vs 3.2 ± 0.6 mmol/L, P < .0001), triglycerides (3.4 ± 2.3 vs 2.4 ± 0.9 mmol/L, P < .05), and insulin sensitivity (3.3 ± 1.7 vs 5.4 ± 1.6 μU × 10-4 min-1 mL-1, P < .0001) after weight loss. Brachial artery compliance (P < .05) and distensibility (P < .05) curves over the physiologic pressure range improved, whereas endothelial function and intima-media thickness remained unchanged. In overweight adults, 6 months of weight loss resulted in improvements in body composition, insulin sensitivity, lipid profile, and brachial artery compliance and distensibility.
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U2 - 10.1016/j.metabol.2006.02.018
DO - 10.1016/j.metabol.2006.02.018
M3 - Article
C2 - 16784962
AN - SCOPUS:33745125879
SN - 0026-0495
VL - 55
SP - 907
EP - 911
JO - Metabolism: Clinical and Experimental
JF - Metabolism: Clinical and Experimental
IS - 7
ER -