Effects of ventricular conduction block patterns on mortality in hospitalized patients with dilated cardiomyopathy: A single-center cohort study

Xiaoping Li, Rong Luo, Wei Fang, Xiaolei H Xu, Guodong Niu, Yixian Xu, Michael Fu, Wei Hua, Xiushan Wu

Research output: Contribution to journalArticle

Abstract

Background: Ventricular conduction blocks (VCBs) are associated with poor outcomes in patients with known cardiac diseases. However, the prognostic implications of VCB patterns in dilated cardiomyopathy (DCM) patients need to be evaluated. The purpose of this study was to determine all-cause mortality in patients with DCM and VCB. Methods: This cohort study included 1119 DCM patients with a median follow-up of 34.3 (19.5-60.8) months, patients were then divided into left bundle branch block (LBBB), right bundle branch block (RBBB), intraventricular conduction delays (IVCD) and narrow QRS groups. The all-cause mortality was assessed using Kaplan-Meier survival curves and Cox regression. Results: Of those 1119 patients, the all-cause mortality rates were highest in patients with IVCD (47.8, n = 32), intermediate in those with RBBB (32.9, n = 27) and LBBB (27.1 %, n = 60), and lowest in those with narrow QRS (19.9 %, n = 149). The all-cause mortality risk was significantly different between the VCB and narrow QRS group (log-rank χ2 = 51.564, P < 0.001). The presence of RBBB, IVCD, PASP ≥ 40 mmHg, left atrium diameter and NYHA functional class were independent predictors of all-cause mortality in DCM patients. Conclusions: Our findings indicate that RBBB and IVCD at admission,but not LBBB, were independent predictors of all-cause mortality in patients with DCM.

Original languageEnglish (US)
Article number136
JournalBMC Cardiovascular Disorders
Volume16
Issue number1
DOIs
StatePublished - Jun 13 2016

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Dilated Cardiomyopathy
Bundle-Branch Block
Cohort Studies
Mortality
Kaplan-Meier Estimate
Heart Atria
Heart Diseases

Keywords

  • Dilated cardiomyopathy
  • Prognosis
  • Pulmonary hypertension
  • Survival
  • Ventricular conduction block

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Effects of ventricular conduction block patterns on mortality in hospitalized patients with dilated cardiomyopathy : A single-center cohort study. / Li, Xiaoping; Luo, Rong; Fang, Wei; Xu, Xiaolei H; Niu, Guodong; Xu, Yixian; Fu, Michael; Hua, Wei; Wu, Xiushan.

In: BMC Cardiovascular Disorders, Vol. 16, No. 1, 136, 13.06.2016.

Research output: Contribution to journalArticle

Li, Xiaoping ; Luo, Rong ; Fang, Wei ; Xu, Xiaolei H ; Niu, Guodong ; Xu, Yixian ; Fu, Michael ; Hua, Wei ; Wu, Xiushan. / Effects of ventricular conduction block patterns on mortality in hospitalized patients with dilated cardiomyopathy : A single-center cohort study. In: BMC Cardiovascular Disorders. 2016 ; Vol. 16, No. 1.
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abstract = "Background: Ventricular conduction blocks (VCBs) are associated with poor outcomes in patients with known cardiac diseases. However, the prognostic implications of VCB patterns in dilated cardiomyopathy (DCM) patients need to be evaluated. The purpose of this study was to determine all-cause mortality in patients with DCM and VCB. Methods: This cohort study included 1119 DCM patients with a median follow-up of 34.3 (19.5-60.8) months, patients were then divided into left bundle branch block (LBBB), right bundle branch block (RBBB), intraventricular conduction delays (IVCD) and narrow QRS groups. The all-cause mortality was assessed using Kaplan-Meier survival curves and Cox regression. Results: Of those 1119 patients, the all-cause mortality rates were highest in patients with IVCD (47.8, n = 32), intermediate in those with RBBB (32.9, n = 27) and LBBB (27.1 {\%}, n = 60), and lowest in those with narrow QRS (19.9 {\%}, n = 149). The all-cause mortality risk was significantly different between the VCB and narrow QRS group (log-rank χ2 = 51.564, P < 0.001). The presence of RBBB, IVCD, PASP ≥ 40 mmHg, left atrium diameter and NYHA functional class were independent predictors of all-cause mortality in DCM patients. Conclusions: Our findings indicate that RBBB and IVCD at admission,but not LBBB, were independent predictors of all-cause mortality in patients with DCM.",
keywords = "Dilated cardiomyopathy, Prognosis, Pulmonary hypertension, Survival, Ventricular conduction block",
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T1 - Effects of ventricular conduction block patterns on mortality in hospitalized patients with dilated cardiomyopathy

T2 - A single-center cohort study

AU - Li, Xiaoping

AU - Luo, Rong

AU - Fang, Wei

AU - Xu, Xiaolei H

AU - Niu, Guodong

AU - Xu, Yixian

AU - Fu, Michael

AU - Hua, Wei

AU - Wu, Xiushan

PY - 2016/6/13

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N2 - Background: Ventricular conduction blocks (VCBs) are associated with poor outcomes in patients with known cardiac diseases. However, the prognostic implications of VCB patterns in dilated cardiomyopathy (DCM) patients need to be evaluated. The purpose of this study was to determine all-cause mortality in patients with DCM and VCB. Methods: This cohort study included 1119 DCM patients with a median follow-up of 34.3 (19.5-60.8) months, patients were then divided into left bundle branch block (LBBB), right bundle branch block (RBBB), intraventricular conduction delays (IVCD) and narrow QRS groups. The all-cause mortality was assessed using Kaplan-Meier survival curves and Cox regression. Results: Of those 1119 patients, the all-cause mortality rates were highest in patients with IVCD (47.8, n = 32), intermediate in those with RBBB (32.9, n = 27) and LBBB (27.1 %, n = 60), and lowest in those with narrow QRS (19.9 %, n = 149). The all-cause mortality risk was significantly different between the VCB and narrow QRS group (log-rank χ2 = 51.564, P < 0.001). The presence of RBBB, IVCD, PASP ≥ 40 mmHg, left atrium diameter and NYHA functional class were independent predictors of all-cause mortality in DCM patients. Conclusions: Our findings indicate that RBBB and IVCD at admission,but not LBBB, were independent predictors of all-cause mortality in patients with DCM.

AB - Background: Ventricular conduction blocks (VCBs) are associated with poor outcomes in patients with known cardiac diseases. However, the prognostic implications of VCB patterns in dilated cardiomyopathy (DCM) patients need to be evaluated. The purpose of this study was to determine all-cause mortality in patients with DCM and VCB. Methods: This cohort study included 1119 DCM patients with a median follow-up of 34.3 (19.5-60.8) months, patients were then divided into left bundle branch block (LBBB), right bundle branch block (RBBB), intraventricular conduction delays (IVCD) and narrow QRS groups. The all-cause mortality was assessed using Kaplan-Meier survival curves and Cox regression. Results: Of those 1119 patients, the all-cause mortality rates were highest in patients with IVCD (47.8, n = 32), intermediate in those with RBBB (32.9, n = 27) and LBBB (27.1 %, n = 60), and lowest in those with narrow QRS (19.9 %, n = 149). The all-cause mortality risk was significantly different between the VCB and narrow QRS group (log-rank χ2 = 51.564, P < 0.001). The presence of RBBB, IVCD, PASP ≥ 40 mmHg, left atrium diameter and NYHA functional class were independent predictors of all-cause mortality in DCM patients. Conclusions: Our findings indicate that RBBB and IVCD at admission,but not LBBB, were independent predictors of all-cause mortality in patients with DCM.

KW - Dilated cardiomyopathy

KW - Prognosis

KW - Pulmonary hypertension

KW - Survival

KW - Ventricular conduction block

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