Effects of vasoactive intestinal peptide and pancreatic polypeptide in rabbit intestine

Michael Camilleri, B. T. Cooper, T. E. Adrian, S. R. Bloom, V. S. Chadwick

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The effects of porcine vasoactive intestinal peptide (VIP) and bovine pancreatic polypeptide (PP) on jejunal, ileal, and colonic fluid transport were studied in the rabbit. VIP produced secretion in the small intestine (jejunum > ileum) but did not affect absorption in the colon. PP had no secretory effects in jejunum, ileum, or colon. The small intestinal secretion induced by VIP was not associated with raised cAMP concentrations in the mucosa; this suggests that the secretory effects of VIP in vivo are mediated by a mechanism other than stimulation of adenylate cyclase.

Original languageEnglish (US)
Pages (from-to)14-18
Number of pages5
JournalGut
Volume22
Issue number1
StatePublished - 1981
Externally publishedYes

Fingerprint

Pancreatic Polypeptide
Vasoactive Intestinal Peptide
Intestines
Rabbits
Jejunum
Ileum
Colon
Intestinal Secretions
Adenylyl Cyclases
Small Intestine
Mucous Membrane
Swine

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Camilleri, M., Cooper, B. T., Adrian, T. E., Bloom, S. R., & Chadwick, V. S. (1981). Effects of vasoactive intestinal peptide and pancreatic polypeptide in rabbit intestine. Gut, 22(1), 14-18.

Effects of vasoactive intestinal peptide and pancreatic polypeptide in rabbit intestine. / Camilleri, Michael; Cooper, B. T.; Adrian, T. E.; Bloom, S. R.; Chadwick, V. S.

In: Gut, Vol. 22, No. 1, 1981, p. 14-18.

Research output: Contribution to journalArticle

Camilleri, M, Cooper, BT, Adrian, TE, Bloom, SR & Chadwick, VS 1981, 'Effects of vasoactive intestinal peptide and pancreatic polypeptide in rabbit intestine', Gut, vol. 22, no. 1, pp. 14-18.
Camilleri M, Cooper BT, Adrian TE, Bloom SR, Chadwick VS. Effects of vasoactive intestinal peptide and pancreatic polypeptide in rabbit intestine. Gut. 1981;22(1):14-18.
Camilleri, Michael ; Cooper, B. T. ; Adrian, T. E. ; Bloom, S. R. ; Chadwick, V. S. / Effects of vasoactive intestinal peptide and pancreatic polypeptide in rabbit intestine. In: Gut. 1981 ; Vol. 22, No. 1. pp. 14-18.
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