Effects of vasoactive intestinal peptide and pancreatic polypeptide in rabbit intestine

M. Camilleri, B. T. Cooper, T. E. Adrian, S. R. Bloom, V. S. Chadwick

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

The effects of porcine vasoactive intestinal peptide (VIP) and bovine pancreatic polypeptide (PP) on jejunal, ileal, and colonic fluid transport were studied in the rabbit. VIP produced secretion in the small intestine (jejunum > ileum) but did not affect absorption in the colon. PP had no secretory effects in jejunum, ileum, or colon. The small intestinal secretion induced by VIP was not associated with raised cAMP concentrations in the mucosa; this suggests that the secretory effects of VIP in vivo are mediated by a mechanism other than stimulation of adenylate cyclase.

Original languageEnglish (US)
Pages (from-to)14-18
Number of pages5
JournalUnknown Journal
Volume22
Issue number1
DOIs
StatePublished - Jan 1 1981

ASJC Scopus subject areas

  • Gastroenterology

Fingerprint Dive into the research topics of 'Effects of vasoactive intestinal peptide and pancreatic polypeptide in rabbit intestine'. Together they form a unique fingerprint.

  • Cite this