Effects of vasoactive intestinal peptide and pancreatic polypeptide in rabbit intestine

M. Camilleri; B. T. Cooper; T. E. Adrian; S. R. Bloom; V. S. Chadwick

doi:10.1136/gut.22.1.14

Effects of vasoactive intestinal peptide and pancreatic polypeptide in rabbit intestine

M. Camilleri, B. T. Cooper, T. E. Adrian, S. R. Bloom, V. S. Chadwick

Gastroenterology and Hepatology

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

The effects of porcine vasoactive intestinal peptide (VIP) and bovine pancreatic polypeptide (PP) on jejunal, ileal, and colonic fluid transport were studied in the rabbit. VIP produced secretion in the small intestine (jejunum > ileum) but did not affect absorption in the colon. PP had no secretory effects in jejunum, ileum, or colon. The small intestinal secretion induced by VIP was not associated with raised cAMP concentrations in the mucosa; this suggests that the secretory effects of VIP in vivo are mediated by a mechanism other than stimulation of adenylate cyclase.

Original language	English (US)
Pages (from-to)	14-18
Number of pages	5
Journal	Unknown Journal
Volume	22
Issue number	1
DOIs	https://doi.org/10.1136/gut.22.1.14
State	Published - 1981

ASJC Scopus subject areas

Gastroenterology

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10.1136/gut.22.1.14

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title = "Effects of vasoactive intestinal peptide and pancreatic polypeptide in rabbit intestine",

abstract = "The effects of porcine vasoactive intestinal peptide (VIP) and bovine pancreatic polypeptide (PP) on jejunal, ileal, and colonic fluid transport were studied in the rabbit. VIP produced secretion in the small intestine (jejunum > ileum) but did not affect absorption in the colon. PP had no secretory effects in jejunum, ileum, or colon. The small intestinal secretion induced by VIP was not associated with raised cAMP concentrations in the mucosa; this suggests that the secretory effects of VIP in vivo are mediated by a mechanism other than stimulation of adenylate cyclase.",

author = "M. Camilleri and Cooper, {B. T.} and Adrian, {T. E.} and Bloom, {S. R.} and Chadwick, {V. S.}",

year = "1981",

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language = "English (US)",

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T1 - Effects of vasoactive intestinal peptide and pancreatic polypeptide in rabbit intestine

AU - Camilleri, M.

AU - Cooper, B. T.

AU - Adrian, T. E.

AU - Bloom, S. R.

AU - Chadwick, V. S.

PY - 1981

Y1 - 1981

N2 - The effects of porcine vasoactive intestinal peptide (VIP) and bovine pancreatic polypeptide (PP) on jejunal, ileal, and colonic fluid transport were studied in the rabbit. VIP produced secretion in the small intestine (jejunum > ileum) but did not affect absorption in the colon. PP had no secretory effects in jejunum, ileum, or colon. The small intestinal secretion induced by VIP was not associated with raised cAMP concentrations in the mucosa; this suggests that the secretory effects of VIP in vivo are mediated by a mechanism other than stimulation of adenylate cyclase.

AB - The effects of porcine vasoactive intestinal peptide (VIP) and bovine pancreatic polypeptide (PP) on jejunal, ileal, and colonic fluid transport were studied in the rabbit. VIP produced secretion in the small intestine (jejunum > ileum) but did not affect absorption in the colon. PP had no secretory effects in jejunum, ileum, or colon. The small intestinal secretion induced by VIP was not associated with raised cAMP concentrations in the mucosa; this suggests that the secretory effects of VIP in vivo are mediated by a mechanism other than stimulation of adenylate cyclase.

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VL - 22

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EP - 18

JO - Unknown Journal

JF - Unknown Journal

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ER -

Effects of vasoactive intestinal peptide and pancreatic polypeptide in rabbit intestine

Abstract

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