Effects of the mueller maneuver on functional mitral regurgitation and implications for obstructive sleep apnea

Gregg S. Pressman, Marek Orban, Pavel Leinveber, Kunal Parekh, Manmeet Singh, Tomas Kara, Virend Somers

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Obstructive sleep apnea is prevalent and adversely affects cardiovascular health. However, little is known of the acute effects of an obstructive apnea on cardiovascular physiology. We hypothesized that pre-existing functional mitral regurgitation (MR) would worsen during performance of a Mueller maneuver (MM) used to simulate an obstructive apnea; 15 subjects with an ejection fraction ≤35% and pre-existing functional MR were studied with Doppler echocardiography. The radius of the proximal flow convergence was used as a measure of mitral regurgitant flow. Measurements were made at baseline, during the MM, and post-MM. Areas of all 4 chambers were also measured at these time points, both in systole and diastole. Mean flow convergence radius for the group decreased significantly during the transition from the late-MM to post-MM (0.65 → 0.57 mm, p = 0.001), implying increased MR during the MM. In addition, in 3 subjects, duration of MR increased during the MM. Right atrial (RA) areas, both systolic and diastolic, increased during the maneuver, whereas RA fractional area change decreased, indicating reduced RA emptying. Left ventricular emptying decreased early in the maneuver, probably because of the increased afterload burden, and then recovered. In conclusion, high negative intrathoracic pressure produces changes that, repeated hundreds of times per night in patients with obstructive sleep apnea, have the potential to worsen heart failure and predispose affected subjects to atrial fibrillation.

Original languageEnglish (US)
Pages (from-to)1563-1567
Number of pages5
JournalAmerican Journal of Cardiology
Volume115
Issue number11
DOIs
StatePublished - Jun 1 2015

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Mitral Valve Insufficiency
Obstructive Sleep Apnea
Apnea
Cardiovascular Physiological Phenomena
Diastole
Doppler Echocardiography
Systole
Atrial Fibrillation
Heart Failure
Pressure
Health

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Effects of the mueller maneuver on functional mitral regurgitation and implications for obstructive sleep apnea. / Pressman, Gregg S.; Orban, Marek; Leinveber, Pavel; Parekh, Kunal; Singh, Manmeet; Kara, Tomas; Somers, Virend.

In: American Journal of Cardiology, Vol. 115, No. 11, 01.06.2015, p. 1563-1567.

Research output: Contribution to journalArticle

Pressman, Gregg S. ; Orban, Marek ; Leinveber, Pavel ; Parekh, Kunal ; Singh, Manmeet ; Kara, Tomas ; Somers, Virend. / Effects of the mueller maneuver on functional mitral regurgitation and implications for obstructive sleep apnea. In: American Journal of Cardiology. 2015 ; Vol. 115, No. 11. pp. 1563-1567.
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