Abstract
Previous studies demonstrated that ∼50% of acute myelogenous leukemia samples exhibit activation of the mitogen-activated protein kinase (MAPK) pathway and growth inhibition by MEK inhibitors. To extend these observations, we assessed MAPK pathway activation and effects of CI-1040 in normal and myelodysplastic (MDS) marrow.
Original language | English (US) |
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Pages (from-to) | 1072-1074 |
Number of pages | 3 |
Journal | Haematologica |
Volume | 88 |
Issue number | 9 |
State | Published - Sep 1 2003 |
Keywords
- MAPK
- MEK inhibitors
ASJC Scopus subject areas
- Hematology