Effects of the dihydropyridine Ca2+ channel antagonist nimodipine on kainic acid-induced limbic seizures

Richard P. Paczynski, Fredric B. Meyer, Robert E. Anderson

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The effects of the dihydropyridine Ca2+ channel antagonist nimodipine on kainic acid-induced seizures were studied in 30 0.5% halothane anesthetized Sprague-Dawley rats. Each animal received low dose kainic acid 0.5 mg/kg i.v. to allow study of the progression of neuronal excitability and epileptiform activity. Preadministration of nimodipine 1.0 mg/kg i.p. increased the latency but did not prevent kainic acid-induced epileptic activity. For example, the latency from kainic acid administration to the appearance of the first seizure and status epilepticus was 75.6 ± 9.1 min and 85.9 ± 9.4 min in control vs. 117.3 ± 9.3 min and 128.0 ± 8.7 min in the nimodipine group (P < 0.005). It is hypothesized that nimodipine attenuated excitability by blocking Ca2+ influx through voltage-dependent L-channel secondary to kainic acid-induced membrane depolarization.

Original languageEnglish (US)
Pages (from-to)33-38
Number of pages6
JournalEpilepsy Research
Volume6
Issue number1
DOIs
StatePublished - 1990

Fingerprint

Nimodipine
Kainic Acid
Seizures
Status Epilepticus
Halothane
Sprague Dawley Rats
1,4-dihydropyridine
Membranes

Keywords

  • Calcium
  • Dihydropyridine
  • Kainic acid
  • Seizure

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Neurology

Cite this

Effects of the dihydropyridine Ca2+ channel antagonist nimodipine on kainic acid-induced limbic seizures. / Paczynski, Richard P.; Meyer, Fredric B.; Anderson, Robert E.

In: Epilepsy Research, Vol. 6, No. 1, 1990, p. 33-38.

Research output: Contribution to journalArticle

Paczynski, Richard P. ; Meyer, Fredric B. ; Anderson, Robert E. / Effects of the dihydropyridine Ca2+ channel antagonist nimodipine on kainic acid-induced limbic seizures. In: Epilepsy Research. 1990 ; Vol. 6, No. 1. pp. 33-38.
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