Effects of the calciotrophic peptides calcitonin and parathyroid hormone on prostate cancer growth and chemotaxis

Candace K. Ritchie, Kris G. Thomas, Laura R. Andrews, Donald J. Tindall, Lorraine A. Fitzpatrick

Research output: Contribution to journalArticle

59 Scopus citations

Abstract

BACKGROUND. The most common site of metastases in prostate cancer is the skeleton and occurs in 70-80% of patients with prostate carcinoma. Calciotrophic peptides are important in the growth and development of normal bone matrix. METHODS. Three human prostate carcinoma cells lines, DU-145, PC- 3, and LNCaP, were exposed to varying concentrations of parathyroid hormone (PTH) or calcitonin (CT). Cell proliferation and chemotaxis were assessed. RESULTS. Proliferation increased in LNCaP cells in a dose-dependent manner following treatment with PTH. Proliferation was not altered in PC-3 cells in response to PTH. Proliferation was decreased in DU-145 and PC-3 cells and increased in LNCaP cells after treatment with CT. Cell chemotaxis was increased in the presence of PTH in DU-145 and PC-3 cells compared to vehicle-treated controls. CONCLUSIONS. The combined proliferation and chemotaxis data suggest that PTH has a dual role in prostate carcinoma resulting in an increase in the number and migration of selected prostate cancer cells. With CT, chemotaxis was unchanged in the DU-145 and PC-3 cells and significantly elevated in the LNCaP cell line. The calciotrophic hormones, PTH and CT, may play an integral role in the regulation of prostate cell growth and metastases.

Original languageEnglish (US)
Pages (from-to)183-187
Number of pages5
JournalProstate
Volume30
Issue number3
DOIs
StatePublished - Feb 15 1997

Keywords

  • DU- 145 cells
  • LNCaP cells
  • PC3 cells
  • calcitonin
  • parathyroid hormone
  • proliferation

ASJC Scopus subject areas

  • Oncology
  • Urology

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