Effects of tacrolimus on ischemia-reperfusion injury

S. D St Peter, Adyr A. Moss, David C. Mulligan

Research output: Contribution to journalReview article

31 Citations (Scopus)

Abstract

In addition to efficacious immunosuppression for the benefit of organ transplantation, tacrolimus has diverse actions that result in amelioration of ischemia-reperfusion injury. Knowledge is accumulating rapidly on the mechanisms through which tacrolimus exerts these cytoprotective effects, including alterations in microcirculation, free radical metabolism, calcium-activated pathways, inflammatory cascades, mitochondrial stability, apoptosis, stress-response proteins, and tissue recovery. Within the nucleus, actions mediating the effects of tacrolimus appear to be dominantly influenced by interactions with the transcription factor, nuclear factor-κB. Because tacrolimus is a cornerstone agent in immunosuppression regimens throughout the world and knowledge of its cellular mechanisms is evolving, it is important to update the clinical literature with this information. We reviewed the published literature with intent to portray the interactions of tacrolimus in the intricate cellular mechanisms initiated by ischemia and reperfusion.

Original languageEnglish (US)
Pages (from-to)105-116
Number of pages12
JournalLiver Transplantation
Volume9
Issue number2
DOIs
StatePublished - Feb 1 2003

Fingerprint

Tacrolimus
Reperfusion Injury
Immunosuppression
Organ Transplantation
Microcirculation
Heat-Shock Proteins
Reperfusion
Free Radicals
Transcription Factors
Ischemia
Apoptosis
Calcium

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

Peter, S. D. S., Moss, A. A., & Mulligan, D. C. (2003). Effects of tacrolimus on ischemia-reperfusion injury. Liver Transplantation, 9(2), 105-116. https://doi.org/10.1053/jlts.2003.50020

Effects of tacrolimus on ischemia-reperfusion injury. / Peter, S. D St ; Moss, Adyr A.; Mulligan, David C.

In: Liver Transplantation, Vol. 9, No. 2, 01.02.2003, p. 105-116.

Research output: Contribution to journalReview article

Peter, SDS, Moss, AA & Mulligan, DC 2003, 'Effects of tacrolimus on ischemia-reperfusion injury', Liver Transplantation, vol. 9, no. 2, pp. 105-116. https://doi.org/10.1053/jlts.2003.50020
Peter, S. D St ; Moss, Adyr A. ; Mulligan, David C. / Effects of tacrolimus on ischemia-reperfusion injury. In: Liver Transplantation. 2003 ; Vol. 9, No. 2. pp. 105-116.
@article{39160a4dd6eb427eaeb18a5922cf2d6e,
title = "Effects of tacrolimus on ischemia-reperfusion injury",
abstract = "In addition to efficacious immunosuppression for the benefit of organ transplantation, tacrolimus has diverse actions that result in amelioration of ischemia-reperfusion injury. Knowledge is accumulating rapidly on the mechanisms through which tacrolimus exerts these cytoprotective effects, including alterations in microcirculation, free radical metabolism, calcium-activated pathways, inflammatory cascades, mitochondrial stability, apoptosis, stress-response proteins, and tissue recovery. Within the nucleus, actions mediating the effects of tacrolimus appear to be dominantly influenced by interactions with the transcription factor, nuclear factor-κB. Because tacrolimus is a cornerstone agent in immunosuppression regimens throughout the world and knowledge of its cellular mechanisms is evolving, it is important to update the clinical literature with this information. We reviewed the published literature with intent to portray the interactions of tacrolimus in the intricate cellular mechanisms initiated by ischemia and reperfusion.",
author = "Peter, {S. D St} and Moss, {Adyr A.} and Mulligan, {David C.}",
year = "2003",
month = "2",
day = "1",
doi = "10.1053/jlts.2003.50020",
language = "English (US)",
volume = "9",
pages = "105--116",
journal = "Liver Transplantation",
issn = "1527-6465",
publisher = "John Wiley and Sons Ltd",
number = "2",

}

TY - JOUR

T1 - Effects of tacrolimus on ischemia-reperfusion injury

AU - Peter, S. D St

AU - Moss, Adyr A.

AU - Mulligan, David C.

PY - 2003/2/1

Y1 - 2003/2/1

N2 - In addition to efficacious immunosuppression for the benefit of organ transplantation, tacrolimus has diverse actions that result in amelioration of ischemia-reperfusion injury. Knowledge is accumulating rapidly on the mechanisms through which tacrolimus exerts these cytoprotective effects, including alterations in microcirculation, free radical metabolism, calcium-activated pathways, inflammatory cascades, mitochondrial stability, apoptosis, stress-response proteins, and tissue recovery. Within the nucleus, actions mediating the effects of tacrolimus appear to be dominantly influenced by interactions with the transcription factor, nuclear factor-κB. Because tacrolimus is a cornerstone agent in immunosuppression regimens throughout the world and knowledge of its cellular mechanisms is evolving, it is important to update the clinical literature with this information. We reviewed the published literature with intent to portray the interactions of tacrolimus in the intricate cellular mechanisms initiated by ischemia and reperfusion.

AB - In addition to efficacious immunosuppression for the benefit of organ transplantation, tacrolimus has diverse actions that result in amelioration of ischemia-reperfusion injury. Knowledge is accumulating rapidly on the mechanisms through which tacrolimus exerts these cytoprotective effects, including alterations in microcirculation, free radical metabolism, calcium-activated pathways, inflammatory cascades, mitochondrial stability, apoptosis, stress-response proteins, and tissue recovery. Within the nucleus, actions mediating the effects of tacrolimus appear to be dominantly influenced by interactions with the transcription factor, nuclear factor-κB. Because tacrolimus is a cornerstone agent in immunosuppression regimens throughout the world and knowledge of its cellular mechanisms is evolving, it is important to update the clinical literature with this information. We reviewed the published literature with intent to portray the interactions of tacrolimus in the intricate cellular mechanisms initiated by ischemia and reperfusion.

UR - http://www.scopus.com/inward/record.url?scp=0037322564&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037322564&partnerID=8YFLogxK

U2 - 10.1053/jlts.2003.50020

DO - 10.1053/jlts.2003.50020

M3 - Review article

C2 - 12548502

AN - SCOPUS:0037322564

VL - 9

SP - 105

EP - 116

JO - Liver Transplantation

JF - Liver Transplantation

SN - 1527-6465

IS - 2

ER -