Effects of size, time of day and sequence of meal ingestion on carbohydrate tolerance in normal subjects

F. J. Service, L. D. Hall, R. E. Westland, P. C. O'Brien, V. L W Go, M. W. Haymond, R. A. Rizza

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

The effects of size, time of day and sequence of meal ingestion were determined in healthy subjects using a Latin square design. Plasma glucose, insulin and gastric inhibitory polypeptide, but not glucagon, were correlated with meal size. Plasma glucose, but not insulin, gastric inhibitory polypeptide or glucagon, were greater later in the day. The progressive decline in carbohydrate tolerance from 08.00 to 18.00 h was associated with impaired insulin secretion estimated by C-peptide, and with impaired insulin action.

Original languageEnglish (US)
Pages (from-to)316-321
Number of pages6
JournalDiabetologia
Volume25
Issue number4
DOIs
StatePublished - Oct 1983

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Meals
Eating
Carbohydrates
Gastric Inhibitory Polypeptide
Insulin
Glucagon
Glucose
C-Peptide
Healthy Volunteers

Keywords

  • carbohydrate tolerance
  • insulin action
  • insulin secretion
  • Meal size
  • sequence
  • time of day

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Service, F. J., Hall, L. D., Westland, R. E., O'Brien, P. C., Go, V. L. W., Haymond, M. W., & Rizza, R. A. (1983). Effects of size, time of day and sequence of meal ingestion on carbohydrate tolerance in normal subjects. Diabetologia, 25(4), 316-321. https://doi.org/10.1007/BF00253193

Effects of size, time of day and sequence of meal ingestion on carbohydrate tolerance in normal subjects. / Service, F. J.; Hall, L. D.; Westland, R. E.; O'Brien, P. C.; Go, V. L W; Haymond, M. W.; Rizza, R. A.

In: Diabetologia, Vol. 25, No. 4, 10.1983, p. 316-321.

Research output: Contribution to journalArticle

Service, FJ, Hall, LD, Westland, RE, O'Brien, PC, Go, VLW, Haymond, MW & Rizza, RA 1983, 'Effects of size, time of day and sequence of meal ingestion on carbohydrate tolerance in normal subjects', Diabetologia, vol. 25, no. 4, pp. 316-321. https://doi.org/10.1007/BF00253193
Service FJ, Hall LD, Westland RE, O'Brien PC, Go VLW, Haymond MW et al. Effects of size, time of day and sequence of meal ingestion on carbohydrate tolerance in normal subjects. Diabetologia. 1983 Oct;25(4):316-321. https://doi.org/10.1007/BF00253193
Service, F. J. ; Hall, L. D. ; Westland, R. E. ; O'Brien, P. C. ; Go, V. L W ; Haymond, M. W. ; Rizza, R. A. / Effects of size, time of day and sequence of meal ingestion on carbohydrate tolerance in normal subjects. In: Diabetologia. 1983 ; Vol. 25, No. 4. pp. 316-321.
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