Effects of size, time of day and sequence of meal ingestion on carbohydrate tolerance in normal subjects

F. J. Service, L. D. Hall, R. E. Westland, P. C. O'Brien, V. L.W. Go, M. W. Haymond, R. A. Rizza

Research output: Contribution to journalArticle

78 Scopus citations

Abstract

The effects of size, time of day and sequence of meal ingestion were determined in healthy subjects using a Latin square design. Plasma glucose, insulin and gastric inhibitory polypeptide, but not glucagon, were correlated with meal size. Plasma glucose, but not insulin, gastric inhibitory polypeptide or glucagon, were greater later in the day. The progressive decline in carbohydrate tolerance from 08.00 to 18.00 h was associated with impaired insulin secretion estimated by C-peptide, and with impaired insulin action.

Original languageEnglish (US)
Pages (from-to)316-321
Number of pages6
JournalDiabetologia
Volume25
Issue number4
DOIs
StatePublished - Oct 1983

Keywords

  • Meal size
  • carbohydrate tolerance
  • insulin action
  • insulin secretion
  • sequence
  • time of day

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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    Service, F. J., Hall, L. D., Westland, R. E., O'Brien, P. C., Go, V. L. W., Haymond, M. W., & Rizza, R. A. (1983). Effects of size, time of day and sequence of meal ingestion on carbohydrate tolerance in normal subjects. Diabetologia, 25(4), 316-321. https://doi.org/10.1007/BF00253193