Effects of size, time of day and sequence of meal ingestion on carbohydrate tolerance in normal subjects

F. J. Service; L. D. Hall; R. E. Westland; P. C. O'Brien; V. L.W. Go; M. W. Haymond; R. A. Rizza

doi:10.1007/BF00253193

Effects of size, time of day and sequence of meal ingestion on carbohydrate tolerance in normal subjects

F. J. Service, L. D. Hall, R. E. Westland, P. C. O'Brien, V. L.W. Go, M. W. Haymond, R. A. Rizza

Endocrinology, Diabetes, Metabolism, and Nutrition

Research output: Contribution to journal › Article › peer-review

79 Scopus citations

Abstract

The effects of size, time of day and sequence of meal ingestion were determined in healthy subjects using a Latin square design. Plasma glucose, insulin and gastric inhibitory polypeptide, but not glucagon, were correlated with meal size. Plasma glucose, but not insulin, gastric inhibitory polypeptide or glucagon, were greater later in the day. The progressive decline in carbohydrate tolerance from 08.00 to 18.00 h was associated with impaired insulin secretion estimated by C-peptide, and with impaired insulin action.

Original language	English (US)
Pages (from-to)	316-321
Number of pages	6
Journal	Diabetologia
Volume	25
Issue number	4
DOIs	https://doi.org/10.1007/BF00253193
State	Published - Oct 1983

Keywords

Meal size
carbohydrate tolerance
insulin action
insulin secretion
sequence
time of day

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism

Access to Document

10.1007/BF00253193

Cite this

@article{2544b6bc20494354b1a42507befb8147,

title = "Effects of size, time of day and sequence of meal ingestion on carbohydrate tolerance in normal subjects",

abstract = "The effects of size, time of day and sequence of meal ingestion were determined in healthy subjects using a Latin square design. Plasma glucose, insulin and gastric inhibitory polypeptide, but not glucagon, were correlated with meal size. Plasma glucose, but not insulin, gastric inhibitory polypeptide or glucagon, were greater later in the day. The progressive decline in carbohydrate tolerance from 08.00 to 18.00 h was associated with impaired insulin secretion estimated by C-peptide, and with impaired insulin action.",

keywords = "Meal size, carbohydrate tolerance, insulin action, insulin secretion, sequence, time of day",

author = "Service, {F. J.} and Hall, {L. D.} and Westland, {R. E.} and O'Brien, {P. C.} and Go, {V. L.W.} and Haymond, {M. W.} and Rizza, {R. A.}",

year = "1983",

month = oct,

doi = "10.1007/BF00253193",

language = "English (US)",

volume = "25",

pages = "316--321",

journal = "Diabetologia",

issn = "0012-186X",

publisher = "Springer Verlag",

number = "4",

}

TY - JOUR

T1 - Effects of size, time of day and sequence of meal ingestion on carbohydrate tolerance in normal subjects

AU - Service, F. J.

AU - Hall, L. D.

AU - Westland, R. E.

AU - O'Brien, P. C.

AU - Go, V. L.W.

AU - Haymond, M. W.

AU - Rizza, R. A.

PY - 1983/10

Y1 - 1983/10

N2 - The effects of size, time of day and sequence of meal ingestion were determined in healthy subjects using a Latin square design. Plasma glucose, insulin and gastric inhibitory polypeptide, but not glucagon, were correlated with meal size. Plasma glucose, but not insulin, gastric inhibitory polypeptide or glucagon, were greater later in the day. The progressive decline in carbohydrate tolerance from 08.00 to 18.00 h was associated with impaired insulin secretion estimated by C-peptide, and with impaired insulin action.

AB - The effects of size, time of day and sequence of meal ingestion were determined in healthy subjects using a Latin square design. Plasma glucose, insulin and gastric inhibitory polypeptide, but not glucagon, were correlated with meal size. Plasma glucose, but not insulin, gastric inhibitory polypeptide or glucagon, were greater later in the day. The progressive decline in carbohydrate tolerance from 08.00 to 18.00 h was associated with impaired insulin secretion estimated by C-peptide, and with impaired insulin action.

KW - Meal size

KW - carbohydrate tolerance

KW - insulin action

KW - insulin secretion

KW - sequence

KW - time of day

UR - http://www.scopus.com/inward/record.url?scp=0020502124&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020502124&partnerID=8YFLogxK

U2 - 10.1007/BF00253193

DO - 10.1007/BF00253193

M3 - Article

C2 - 6357914

AN - SCOPUS:0020502124

SN - 0012-186X

VL - 25

SP - 316

EP - 321

JO - Diabetologia

JF - Diabetologia

IS - 4

ER -

Effects of size, time of day and sequence of meal ingestion on carbohydrate tolerance in normal subjects

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this