Effects of reaction conditions on rates of incorporation of no-carrier added F-18 fluoride into several organic compounds

M. L. Korguth, Timothy R DeGrado, J. E. Holden, S. J. Gatley

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Apparent rate constants (fractional incorporation per minute per mole of organic reactant) were determined for reaction of no-carrier added F-18 fluoride with several aliphatic and aromatic substrates in acetonitrile or DMSO. No large differences were seen between tetraethylammonium and potassium Kryptofix-2,2,2 as supporting cation. Three hexose derivatives with triflate or cyclic sulfate leaving groups all gave apparent rate constants (obtained by dividing fractional incorporation by time in minutes and by molar concentration of reactant) near 0.4 at 23° and 5 at 55°. An aliphatic iodide reacted ten times more slowly. Aromatic substrates tested showed a wide range of rate constants from > 50 at 23° (isotope exchange in 2,4-dinitrofluorobenzene) to 0.6 at 134° (p-nitroacetophenone).

Original languageEnglish (US)
Pages (from-to)369-381
Number of pages13
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume25
Issue number4
StatePublished - 1988
Externally publishedYes

Fingerprint

Dinitrofluorobenzene
Tetraethylammonium
Hexoses
Iodides
Dimethyl Sulfoxide
Fluorides
Organic compounds
Isotopes
Sulfates
Cations
Rate constants
Potassium
Substrates
Derivatives
4-nitroacetophenone
acetonitrile

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Molecular Medicine
  • Analytical Chemistry
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

Cite this

Effects of reaction conditions on rates of incorporation of no-carrier added F-18 fluoride into several organic compounds. / Korguth, M. L.; DeGrado, Timothy R; Holden, J. E.; Gatley, S. J.

In: Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 25, No. 4, 1988, p. 369-381.

Research output: Contribution to journalArticle

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