Effects of Puerariae radix on cell proliferation and nitric oxide synthase expression in dentate gyrus of alcohol-intoxicated Sprague-Dawley rats

Mi Hyeon Jang, Min Chul Shin, Joo Ho Chung, Hyun Dae Shin, Yeunhee Kim, Ee Hwa Kim, Chang Ju Kim

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Traditionally, Puerariae radix had been used for the treatment of alcohol-related problems. In this study, effects of Puerariae radix on cell proliferation and nitric oxide synthase expression in the dentate gyrus of alcohol-intoxicated Sprague-Dawley rats were investigated via 5-bromo-2′-deoxyuridine (BrdU) immunohistochemistry and nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) histochemistry. Alcohol administration was shown to inhibit the numbers of both BrdU-positive and NADPH-d-positive cells, while Puerariae radix treatment was shown to increase those numbers. It is possible that nitric oxide, which might play an important role in the regulation of cell proliferation, is a major target of the toxic effects of alcohol.

Original languageEnglish (US)
Pages (from-to)355-358
Number of pages4
JournalJapanese Journal of Pharmacology
Volume88
Issue number3
DOIs
StatePublished - Apr 23 2002

Keywords

  • Alcohol
  • Immunohistochemistry
  • Puerariae radix

ASJC Scopus subject areas

  • Pharmacology

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