Effects of preganglionic sympathectomy on peptides in the rat superior cervical ganglion

A. Dagerlind, X. Zhang, William Stephen Brimijoin, B. Lindh, T. Hokfelt

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

A novel method to selectively lesion preganglionic sympathetic neurones has been combined with immunohistochemistry to study the expression of peptides in the rat superior cervical ganglion (SCG). Thus, systemic administration of monoclonal antibodies against acetylcholinesterase (AChE) caused a marked reduction in the number of enkephalin (ENK)-positive fibres and a total disappearance of fibres immunoreactive for calcitonin gene-related peptide (CGRP) and AChE in the SCG. A marked increase in the number of galanin/galanin message-associated peptide (GAL/GMAP)-immunoreactive cell bodies was also observed. The present results indicate that probably all CGRP and most ENK containing fibres in the rat SCG are of preganglionic origin and that peptides not normally expressed in SCG neurones, e.g. GAL and GMAP, can be upregulated after deafferentation.

Original languageEnglish (US)
Pages (from-to)909-912
Number of pages4
JournalNeuroReport
Volume5
Issue number8
StatePublished - 1994

Fingerprint

Superior Cervical Ganglion
Sympathectomy
Peptides
Calcitonin Gene-Related Peptide
Enkephalins
Acetylcholinesterase
Galanin
Neurons
Immunohistochemistry
Monoclonal Antibodies

Keywords

  • acetylcholinesterase
  • calcitonin gene-related peptide
  • deafferentation
  • enkephalin
  • galanin
  • galanin message-associated peptide
  • immunohistochemistry

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Dagerlind, A., Zhang, X., Brimijoin, W. S., Lindh, B., & Hokfelt, T. (1994). Effects of preganglionic sympathectomy on peptides in the rat superior cervical ganglion. NeuroReport, 5(8), 909-912.

Effects of preganglionic sympathectomy on peptides in the rat superior cervical ganglion. / Dagerlind, A.; Zhang, X.; Brimijoin, William Stephen; Lindh, B.; Hokfelt, T.

In: NeuroReport, Vol. 5, No. 8, 1994, p. 909-912.

Research output: Contribution to journalArticle

Dagerlind, A, Zhang, X, Brimijoin, WS, Lindh, B & Hokfelt, T 1994, 'Effects of preganglionic sympathectomy on peptides in the rat superior cervical ganglion', NeuroReport, vol. 5, no. 8, pp. 909-912.
Dagerlind, A. ; Zhang, X. ; Brimijoin, William Stephen ; Lindh, B. ; Hokfelt, T. / Effects of preganglionic sympathectomy on peptides in the rat superior cervical ganglion. In: NeuroReport. 1994 ; Vol. 5, No. 8. pp. 909-912.
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