Effects of Plasma Transfusion on Perioperative Bleeding Complications: A Machine Learning Approach

Che Ngufor, Dennis Murphree, Sudhindra Upadhyaya, Nageswar Madde, Daryl Kor, Jyotishman Pathak

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations

Abstract

Perioperative bleeding (PB) is associated with increased patient morbidity and mortality, and results in substantial health care resource utilization. To assess bleeding risk, a routine practice in most centers is to use indicators such as elevated values of the International Normalized Ratio (INR). For patients with elevated INR, the routine therapy option is plasma transfusion. However, the predictive accuracy of INR and the value of plasma transfusion still remains unclear. Accurate methods are therefore needed to identify early the patients with increased risk of bleeding. The goal of this work is to apply advanced machine learning methods to study the relationship between preoperative plasma transfusion (PPT) and PB in patients with elevated INR undergoing noncardiac surgery. The problem is cast under the framework of causal inference where robust meaningful measures to quantify the effect of PPT on PB are estimated. Results show that both machine learning and standard statistical methods generally agree that PPT negatively impacts PB and other important patient outcomes. However, machine learning methods show significant results, and machine learning boosting methods are found to make less errors in predicting PB.

Original languageEnglish (US)
Title of host publicationMEDINFO 2015
Subtitle of host publicationeHealth-Enabled Health - Proceedings of the 15th World Congress on Health and Biomedical Informatics
EditorsAndrew Georgiou, Indra Neil Sarkar, Paulo Mazzoncini de Azevedo Marques
PublisherIOS Press
Pages721-725
Number of pages5
ISBN (Electronic)9781614995630
DOIs
StatePublished - 2015
Event15th World Congress on Health and Biomedical Informatics, MEDINFO 2015 - Sao Paulo, Brazil
Duration: Aug 19 2015Aug 23 2015

Publication series

NameStudies in Health Technology and Informatics
Volume216
ISSN (Print)0926-9630
ISSN (Electronic)1879-8365

Other

Other15th World Congress on Health and Biomedical Informatics, MEDINFO 2015
CountryBrazil
CitySao Paulo
Period8/19/158/23/15

Keywords

  • Bleeding
  • Blood Transfusion
  • Classification
  • Electronic Health Records
  • Machine Learning
  • Treatment Effect

ASJC Scopus subject areas

  • Biomedical Engineering
  • Health Informatics
  • Health Information Management

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