Effects of Paeonia radix on 5-hydroxytryptamine synthesis and tryptophan hydroxylase expression in the dorsal raphe of exercised rats

Jung Ae Hong, Seok Hee Chung, Jong Soo Lee, Sung Soo Kim, Hyun Dae Shin, Hong Kim, Mi Hyeon Jang, Taeck Hyun Lee, Baek Vin Lim, Young Pyo Kim, Chang Ju Kim

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Paeonia radix is the root of Paeonia japonica MIYABE, a perennial plant classified in the family Paeoniaceae. In the present study, the effects of Paeonia radix on performance in treadmill exercise, and 5-hydroxytryptamine (5-HT) synthesis and tryptophan hydroxylase (TPH) expression in the dorsal raphe were investigated. Time to exhaustion in treadmill exercise was increased and exercise-induced increases in 5-HT synthesis and TPH expression in the dorsal raphe were shown to be suppressed by Paeonia radix treatment; 5-HT synthesis and TPH expression were inhibited by Paeonia radix treatment under resting conditions as well. In sum, treatment with Paeonia radix, inhibiting 5-HT synthesis and TPH expression, may bring about reduced fatigue, both during exercise and the resting state.

Original languageEnglish (US)
Pages (from-to)166-169
Number of pages4
JournalBiological and Pharmaceutical Bulletin
Volume26
Issue number2
DOIs
StatePublished - Feb 1 2003

Keywords

  • 5-hydroxytryptamine
  • Paeonia radix
  • Treadmill exercise
  • Tryptophan hydroxylase

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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    Hong, J. A., Chung, S. H., Lee, J. S., Kim, S. S., Shin, H. D., Kim, H., Jang, M. H., Lee, T. H., Lim, B. V., Kim, Y. P., & Kim, C. J. (2003). Effects of Paeonia radix on 5-hydroxytryptamine synthesis and tryptophan hydroxylase expression in the dorsal raphe of exercised rats. Biological and Pharmaceutical Bulletin, 26(2), 166-169. https://doi.org/10.1248/bpb.26.166