Abstract
Paeonia radix is the root of Paeonia japonica MIYABE, a perennial plant classified in the family Paeoniaceae. In the present study, the effects of Paeonia radix on performance in treadmill exercise, and 5-hydroxytryptamine (5-HT) synthesis and tryptophan hydroxylase (TPH) expression in the dorsal raphe were investigated. Time to exhaustion in treadmill exercise was increased and exercise-induced increases in 5-HT synthesis and TPH expression in the dorsal raphe were shown to be suppressed by Paeonia radix treatment; 5-HT synthesis and TPH expression were inhibited by Paeonia radix treatment under resting conditions as well. In sum, treatment with Paeonia radix, inhibiting 5-HT synthesis and TPH expression, may bring about reduced fatigue, both during exercise and the resting state.
Original language | English (US) |
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Pages (from-to) | 166-169 |
Number of pages | 4 |
Journal | Biological and Pharmaceutical Bulletin |
Volume | 26 |
Issue number | 2 |
DOIs | |
State | Published - Feb 2003 |
Keywords
- 5-hydroxytryptamine
- Paeonia radix
- Treadmill exercise
- Tryptophan hydroxylase
ASJC Scopus subject areas
- Pharmacology
- Pharmaceutical Science