EFFECTS OF MICROEMBOLIZATION ON THE SKELETAL MUSCLE BLOOD FLOW. A Critique of the Microvascular Occlusion Model of Duchenne Dystrophy

Gudrun Boysen, Andrew G. Engel

Research output: Contribution to journalArticle

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Abstract

Muscle blood flow (MBF) during exercise was determined in both anterior tibial muscles of 12 rabbits by the local 133Xe method before and after embolization of 20 to 80 μm dextran particles into the right femoral artery. With a relatively low dose of particles (dry weight: 8.7 mg), MBF was significantly decreased up to 4 days after each embolization, and mild histologic abnormalities were observed in the embolized muscles. A four‐fold higher dose resulted in a marked and permanent decrease of the MBF, ischemic necrosis of the distal leg muscles and toe gangrene. In the light of these findings and the previously demonstrated normal MBF in Duchenne dystrophy, the validity of the assumption that Duchenne dystrophy is caused by small vessel occlusions is questioned.

Original languageEnglish (US)
Pages (from-to)71-80
Number of pages10
JournalActa neurologica Scandinavica
Volume52
Issue number1
DOIs
StatePublished - Jul 1975

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ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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