Effects of long-term transdermal administration of estradiol on serum lipids

Steven J. Ory, Charles S. Field, Rebekah R. Herrmann, Alan R. Zinsmeister, B. Lawrence Riggs

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Objective: To evaluate the effect of three different dosages of transdermally administered 17β-estradiol on serum lipoproteins in women who had recently experienced surgical menopause. Material and Methods: We undertook a 2-year, randomized, double-blind, placebo-controlled study in which 126 subjects were recruited and stratified by age, and 93 patients completed the protocol. Serum lipoproteins were assessed before initiation of treatment and after 12 and 24 months of therapy with 0.025, 0.05, or 0.1 mg of estradiol daily. Results: Total serum cholesterol and low-density lipoprotein cholesterol showed dose-dependent decreases that reached statistical significance after 2 years of treatment with transdermally administered estradiol. Conclusion: This study confirms that transdermally administered 17β-estradiol has a modest beneficial effect on serum lipoproteins, with decreased levels of total cholesterol and low-density lipoprotein cholesterol.

Original languageEnglish (US)
Pages (from-to)735-738
Number of pages4
JournalMayo Clinic Proceedings
Volume73
Issue number8
StatePublished - 1998
Externally publishedYes

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Cutaneous Administration
Estradiol
Lipoproteins
Lipids
Serum
LDL Cholesterol
Cholesterol
Menopause
Therapeutics
Placebos

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Ory, S. J., Field, C. S., Herrmann, R. R., Zinsmeister, A. R., & Lawrence Riggs, B. (1998). Effects of long-term transdermal administration of estradiol on serum lipids. Mayo Clinic Proceedings, 73(8), 735-738.

Effects of long-term transdermal administration of estradiol on serum lipids. / Ory, Steven J.; Field, Charles S.; Herrmann, Rebekah R.; Zinsmeister, Alan R.; Lawrence Riggs, B.

In: Mayo Clinic Proceedings, Vol. 73, No. 8, 1998, p. 735-738.

Research output: Contribution to journalArticle

Ory, SJ, Field, CS, Herrmann, RR, Zinsmeister, AR & Lawrence Riggs, B 1998, 'Effects of long-term transdermal administration of estradiol on serum lipids', Mayo Clinic Proceedings, vol. 73, no. 8, pp. 735-738.
Ory SJ, Field CS, Herrmann RR, Zinsmeister AR, Lawrence Riggs B. Effects of long-term transdermal administration of estradiol on serum lipids. Mayo Clinic Proceedings. 1998;73(8):735-738.
Ory, Steven J. ; Field, Charles S. ; Herrmann, Rebekah R. ; Zinsmeister, Alan R. ; Lawrence Riggs, B. / Effects of long-term transdermal administration of estradiol on serum lipids. In: Mayo Clinic Proceedings. 1998 ; Vol. 73, No. 8. pp. 735-738.
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