Effects of linearly polarized 0.6-1.6 μM irradiation on stellate ganglion function in normal subjects and people with complex regional pain (CRPS I)

Jeffrey R. Basford, Paola Sandroni, Phillip Anson Low, Stacy M. Hines, Jade A. Gehrking, Tonette L. Gehrking

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background and Objectives: Stellate ganglion blocks are an effective but invasive treatment of upper extremity pain. Linearly polarized red and near-infrared (IR) light is promoted as a safe alternative to this procedure, but its effects are poorly established. This study was designed to assess the physiological effects of this latter approach and to quantitate its benefits in people with upper extremity pain due to Complex Regional Pain Syndrome I (CRPS I, RSD). Study Design/Materials and Methods: This was a two-part study. In the first phase, six adults (ages 18-60) with normal neurological examinations underwent transcutaneous irradiation of their right stellate ganglion with linearly polarized 0.6-1.6 μm light (0.92 W, 88.3 J). Phase two consisted of a double-blinded evaluation of active and placebo radiation in 12 subjects (ages 18-72) of which 6 had upper extremity CRPS I and 6 served as "normal" controls. Skin temperature, heart rate (HR), sudomotor function, and vasomotor tone were monitored before, during, and for 30 minutes following irradiation. Analgesic and sensory effects were assessed over the same period as well as 1 and 2 weeks later. Results: Three of six subjects with CRPS I and no control subjects experienced a sensation of warmth following active irradiation (P = 0.025). Two of the CRPS I subjects reported a > 50% pain reduction. However, four noted minimal or no change and improvement did not reach statistical significance for the group as a whole. No statistically significant changes in autonomic function were noted. There were no adverse consequences. Conclusions: Irradiation is well tolerated. There is a suggestion in this small study that treatment is beneficial and that its benefits are not dependent on changes in sympathetic tone. Further evaluation is warranted.

Original languageEnglish (US)
Pages (from-to)417-423
Number of pages7
JournalLasers in Surgery and Medicine
Volume32
Issue number5
DOIs
StatePublished - 2003

Fingerprint

Stellate Ganglion
Upper Extremity
Pain
Complex Regional Pain Syndromes
Light
Skin Temperature
Neurologic Examination
Analgesics
Heart Rate
Placebos
Radiation
Therapeutics

Keywords

  • Autonomic nervous system
  • Complex regional pain syndrome
  • Laser therapy
  • Light therapy
  • Stellate ganglion

ASJC Scopus subject areas

  • Surgery

Cite this

Effects of linearly polarized 0.6-1.6 μM irradiation on stellate ganglion function in normal subjects and people with complex regional pain (CRPS I). / Basford, Jeffrey R.; Sandroni, Paola; Low, Phillip Anson; Hines, Stacy M.; Gehrking, Jade A.; Gehrking, Tonette L.

In: Lasers in Surgery and Medicine, Vol. 32, No. 5, 2003, p. 417-423.

Research output: Contribution to journalArticle

Basford, Jeffrey R. ; Sandroni, Paola ; Low, Phillip Anson ; Hines, Stacy M. ; Gehrking, Jade A. ; Gehrking, Tonette L. / Effects of linearly polarized 0.6-1.6 μM irradiation on stellate ganglion function in normal subjects and people with complex regional pain (CRPS I). In: Lasers in Surgery and Medicine. 2003 ; Vol. 32, No. 5. pp. 417-423.
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AU - Hines, Stacy M.

AU - Gehrking, Jade A.

AU - Gehrking, Tonette L.

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AB - Background and Objectives: Stellate ganglion blocks are an effective but invasive treatment of upper extremity pain. Linearly polarized red and near-infrared (IR) light is promoted as a safe alternative to this procedure, but its effects are poorly established. This study was designed to assess the physiological effects of this latter approach and to quantitate its benefits in people with upper extremity pain due to Complex Regional Pain Syndrome I (CRPS I, RSD). Study Design/Materials and Methods: This was a two-part study. In the first phase, six adults (ages 18-60) with normal neurological examinations underwent transcutaneous irradiation of their right stellate ganglion with linearly polarized 0.6-1.6 μm light (0.92 W, 88.3 J). Phase two consisted of a double-blinded evaluation of active and placebo radiation in 12 subjects (ages 18-72) of which 6 had upper extremity CRPS I and 6 served as "normal" controls. Skin temperature, heart rate (HR), sudomotor function, and vasomotor tone were monitored before, during, and for 30 minutes following irradiation. Analgesic and sensory effects were assessed over the same period as well as 1 and 2 weeks later. Results: Three of six subjects with CRPS I and no control subjects experienced a sensation of warmth following active irradiation (P = 0.025). Two of the CRPS I subjects reported a > 50% pain reduction. However, four noted minimal or no change and improvement did not reach statistical significance for the group as a whole. No statistically significant changes in autonomic function were noted. There were no adverse consequences. Conclusions: Irradiation is well tolerated. There is a suggestion in this small study that treatment is beneficial and that its benefits are not dependent on changes in sympathetic tone. Further evaluation is warranted.

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