Effects of left ventricular assist devices on outcomes in patients undergoing heart transplantation

Alan J. Bank, Sajad H. Mir, Duc Q. Nguyen, R. Morton Bolman, Sara J. Shumway, Leslie W. Miller, Daniel R. Kaiser, Sofia M. Ormaza, Soon J. Park

Research output: Contribution to journalArticle

100 Scopus citations

Abstract

Background. Left ventricular assist devices (LVADs) are increasingly being used to 'bridge' patients to heart transplantation. Methods. Data from 40 consecutive status 1 heart transplantation patients treated with intravenous inotrope therapy (n = 20) or the HeartMate LVAD (n = 20) were retrospectively analyzed. Results. Baseline clinical characteristics were similar in the two groups. At the time of transplantation, LVAD patients had significantly higher blood pressure and sodium with significantly lower blood urea nitrogen and creatinine. After transplantation, renal failure (52.6% versus 16.7%) and right heart failure (31.6% versus 5.6%) occurred more frequently (p < 0.05) in the inotrope group. Six-month survival after transplantation did not significantly differ in the inotrope or LVAD groups (73.7% versus 88.9%) but event-free survival was significantly (p < 0.05) lower in the inotrope group (15.8% versus 55.6%). Total hospital charges were significantly lower in the inotrope group ($213,860 ± $107,560 versus $342,620 ± $104,420), but average daily hospital charges were not different ($3,990 ± $1,300 versus $4,130 ± $2,050). Conclusions. Status 1 heart transplant patients treated with an LVAD as opposed to inotrope therapy have improved clinical and metabolic function at the time of transplant and improved survival to 6 months after transplant without major complications. Total costs are higher in the LVAD patients but average daily costs are similar. (C) 2000 by The Society of Thoracic Surgeons.

Original languageEnglish (US)
Pages (from-to)1369-1374
Number of pages6
JournalAnnals of Thoracic Surgery
Volume69
Issue number5
DOIs
StatePublished - May 2000

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ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Bank, A. J., Mir, S. H., Nguyen, D. Q., Bolman, R. M., Shumway, S. J., Miller, L. W., Kaiser, D. R., Ormaza, S. M., & Park, S. J. (2000). Effects of left ventricular assist devices on outcomes in patients undergoing heart transplantation. Annals of Thoracic Surgery, 69(5), 1369-1374. https://doi.org/10.1016/S0003-4975(00)01083-3