Effects of L-THP on Ca2+ overload of cultured rat cardiomyocytes during hypoxia and reoxygenation

Zeng Qiutang, Zhu Wuqiang, Cao Linsheng, Liu Fang

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

The effects of L-tetrahydropalmatine (L-THP) on the cultured rat cardiomyocytes during hypoxia and reoxygenation and the mechanism of L-THP treating reperfusion-arrythmias were studied. The concentration of intracellular free calcium ([Ca2+]i) of single cultured ventricular myocyte was determined by using EPC-9 light-electricity measurement system. It was found that L-THP (100 mumol/L) could reduce the [Ca2+]i augmentation in single cultured ventricular myocyte during hypoxia and reoxygenation. Verapamil (10 mumol/L) had the similar effect. It was concluded that L-THP could inhibit the Ca2+ overload of cultured rat cardiomyocytes during hypoxia and reoxygenation.

Original languageEnglish (US)
Pages (from-to)294-296
Number of pages3
JournalCurrent Medical Science
Volume20
Issue number4
DOIs
StatePublished - 2000

ASJC Scopus subject areas

  • Management of Technology and Innovation

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