Abstract
The effects of L-tetrahydropalmatine (L-THP) on the cultured rat cardiomyocytes during hypoxia and reoxygenation and the mechanism of L-THP treating reperfusion-arrythmias were studied. The concentration of intracellular free calcium ([Ca2+]i) of single cultured ventricular myocyte was determined by using EPC-9 light-electricity measurement system. It was found that L-THP (100 mumol/L) could reduce the [Ca2+]i augmentation in single cultured ventricular myocyte during hypoxia and reoxygenation. Verapamil (10 mumol/L) had the similar effect. It was concluded that L-THP could inhibit the Ca2+ overload of cultured rat cardiomyocytes during hypoxia and reoxygenation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 294-296 |
| Number of pages | 3 |
| Journal | Current Medical Science |
| Volume | 20 |
| Issue number | 4 |
| DOIs | |
| State | Published - 2000 |
ASJC Scopus subject areas
- Management of Technology and Innovation