Effects of intermittent reperfusion during temporal focal ischemia

M. S. Goldman, R. E. Anderson, F. B. Meyer

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

There is controversy regarding the role of intermittent reperfusion employed as a cerebroprotective measure when temporary arterial occlusion is necessary during repair of difficult aneurysms. The intraluminal suture middle cerebral artery (MCA) occlusion technique was used in 23 Wistar rats under barbiturate anesthesia to induce 60, 90, or 120 minutes of uninterrupted MCA occlusion. The total infarcted areas obtained were compared to those occurring in 27 animals subjected to identical cumulative ischemic periods but with 5 minutes of reperfusion after every 10-minute ischemic period. The mean total infarcted areas in the groups with 60-minute (1.8 ± 0.89 sq mm), 90-minute (1.08 ± 1.02 sq mm), and 120-minute (8.72 ± 5.89 sq mm) intermittent reperfusion were significantly smaller than those occurring in the 60-minute (12.02 ± 3.10 sq mm), 90-minute (11.54 ± 2.68 sq mm), or 120-minute (30.43 ± 6.51 sq mm) control groups, respectively (p < 0.05). Furthermore, there was no difference in the occurrence of blood-brain barrier breakdown, intraparenchymal hemorrhage, hemispheric edema, or seizures between control and intermittent reperfusion groups. The results support the hypothesis that intermittent reperfusion is beneficial if vessel occlusion is required during aneurysm repair.

Original languageEnglish (US)
Pages (from-to)911-916
Number of pages6
JournalJournal of neurosurgery
Volume77
Issue number6
DOIs
StatePublished - Jan 1 1992

Keywords

  • aneurysm
  • cerebral ischemia
  • cerebral protection
  • reperfusion

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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