Effects of indomethacin on cerebrovascular response to hypercapnea and hypocapnea in breath-hold diving and obstructive sleep apnea

Vladimir Ivancev, Darija Bakovic, Ante Obad, Toni Breskovic, Ivan Palada, Michael J. Joyner, Zeljko Dujic

Research output: Contribution to journalArticle

12 Scopus citations


We tested whether breath hold divers (BHD) and obstructive sleep apnea (OSA) subjects had similar middle cerebral artery velocity (MCAV) responses to hypercapnea and hypocapnea. We analyzed changes in MCAV (cm/s) in response to hypocapnea and hyperoxic hypercapnea during placebo or after 90 min of oral indomethacin (100 mg) in BHD (N = 7) and OSA (N = 7). During control hypercapnea MCAV increased for 54.4% in BHD and 48.4% in OSA. Indomethacin blunted the MCAV increase in response to hypercapnea in BHD (P = 0.02), but not in OSA. Indomethacin attenuated the mean arterial pressure response in BHD, but not in OSA. The blunted MCAV responses to hypercapnea with indomethacin in BHD, but not in OSA patients suggests that (a) the normal contribution of local vasodilating mechanisms to the cerebrovascular responses to hypercapnea is absent in OSA patients and (b) exposure to chronic/repeated apneas is not causal per se in limiting the contribution of vasodilating mechanisms to the cerebrovascular responses to hypercapnea in OSA.

Original languageEnglish (US)
Pages (from-to)152-158
Number of pages7
JournalRespiratory Physiology and Neurobiology
Issue number3
StatePublished - May 15 2009



  • Cerebral blood flow
  • Hypercapnic challenge
  • Hypocapnic challenge
  • OSA
  • Transcranial Doppler

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology
  • Pulmonary and Respiratory Medicine

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