Effects of hyperoxia on the developing airway and pulmonary vasculature

Christina M. Pabelick; Michael A. Thompson; Rodney D. Britt

doi:10.1007/978-3-319-63245-2_11

Effects of hyperoxia on the developing airway and pulmonary vasculature

Christina M. Pabelick, Michael A. Thompson, Rodney D. Britt

Research output: Chapter in Book/Report/Conference proceeding › Chapter

7 Scopus citations

Abstract

Although it is necessary and part of standard practice, supplemental oxygen (40–90% O₂) or hyperoxia is a significant contributing factor to development of bronchopulmonary dysplasia, persistent pulmonary hypertension, recurrent wheezing, and asthma in preterm infants. This chapter discusses hyperoxia and the role of redox signaling in the context of neonatal lung growth and disease. Here, we discuss how hyperoxia promotes dysfunction in the airway and the known redox-mediated mechanisms that are important for postnatal vascular and alveolar development. Whether in the airway or alveoli, redox pathways are important and greatly influence the neonatal lung.

Original language	English (US)
Title of host publication	Advances in Experimental Medicine and Biology
Publisher	Springer New York LLC
Pages	179-194
Number of pages	16
DOIs	https://doi.org/10.1007/978-3-319-63245-2_11
State	Published - 2017

Publication series

Name	Advances in Experimental Medicine and Biology
Volume	967
ISSN (Print)	0065-2598
ISSN (Electronic)	2214-8019

Keywords

Alveologenesis
Heme oxygenase-1
Hyperoxia
Hypoxia inducible factor nitric oxide
Lung development
Nuclear factor E2-related factor 2
Pulmonary vasculogenesis redox signaling
Soluble guanylate cyclase
Vascular endothelial growth factor

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

Access to Document

10.1007/978-3-319-63245-2_11

Cite this

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title = "Effects of hyperoxia on the developing airway and pulmonary vasculature",

abstract = "Although it is necessary and part of standard practice, supplemental oxygen (40–90% O2) or hyperoxia is a significant contributing factor to development of bronchopulmonary dysplasia, persistent pulmonary hypertension, recurrent wheezing, and asthma in preterm infants. This chapter discusses hyperoxia and the role of redox signaling in the context of neonatal lung growth and disease. Here, we discuss how hyperoxia promotes dysfunction in the airway and the known redox-mediated mechanisms that are important for postnatal vascular and alveolar development. Whether in the airway or alveoli, redox pathways are important and greatly influence the neonatal lung.",

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author = "Pabelick, {Christina M.} and Thompson, {Michael A.} and Britt, {Rodney D.}",

note = "Publisher Copyright: {\textcopyright} 2017, Springer International Publishing AG.",

year = "2017",

doi = "10.1007/978-3-319-63245-2_11",

language = "English (US)",

series = "Advances in Experimental Medicine and Biology",

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T1 - Effects of hyperoxia on the developing airway and pulmonary vasculature

AU - Pabelick, Christina M.

AU - Thompson, Michael A.

AU - Britt, Rodney D.

PY - 2017

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N2 - Although it is necessary and part of standard practice, supplemental oxygen (40–90% O2) or hyperoxia is a significant contributing factor to development of bronchopulmonary dysplasia, persistent pulmonary hypertension, recurrent wheezing, and asthma in preterm infants. This chapter discusses hyperoxia and the role of redox signaling in the context of neonatal lung growth and disease. Here, we discuss how hyperoxia promotes dysfunction in the airway and the known redox-mediated mechanisms that are important for postnatal vascular and alveolar development. Whether in the airway or alveoli, redox pathways are important and greatly influence the neonatal lung.

AB - Although it is necessary and part of standard practice, supplemental oxygen (40–90% O2) or hyperoxia is a significant contributing factor to development of bronchopulmonary dysplasia, persistent pulmonary hypertension, recurrent wheezing, and asthma in preterm infants. This chapter discusses hyperoxia and the role of redox signaling in the context of neonatal lung growth and disease. Here, we discuss how hyperoxia promotes dysfunction in the airway and the known redox-mediated mechanisms that are important for postnatal vascular and alveolar development. Whether in the airway or alveoli, redox pathways are important and greatly influence the neonatal lung.

KW - Alveologenesis

KW - Heme oxygenase-1

KW - Hyperoxia

KW - Hypoxia inducible factor nitric oxide

KW - Lung development

KW - Nuclear factor E2-related factor 2

KW - Pulmonary vasculogenesis redox signaling

KW - Soluble guanylate cyclase

KW - Vascular endothelial growth factor

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DO - 10.1007/978-3-319-63245-2_11

M3 - Chapter

C2 - 29047087

AN - SCOPUS:85031997147

T3 - Advances in Experimental Medicine and Biology

SP - 179

EP - 194

BT - Advances in Experimental Medicine and Biology

PB - Springer New York LLC

ER -

Effects of hyperoxia on the developing airway and pulmonary vasculature

Abstract

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Keywords

ASJC Scopus subject areas

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