Effects of hyperoxia on the developing airway and pulmonary vasculature

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Citations (Scopus)

Abstract

Although it is necessary and part of standard practice, supplemental oxygen (40–90% O2) or hyperoxia is a significant contributing factor to development of bronchopulmonary dysplasia, persistent pulmonary hypertension, recurrent wheezing, and asthma in preterm infants. This chapter discusses hyperoxia and the role of redox signaling in the context of neonatal lung growth and disease. Here, we discuss how hyperoxia promotes dysfunction in the airway and the known redox-mediated mechanisms that are important for postnatal vascular and alveolar development. Whether in the airway or alveoli, redox pathways are important and greatly influence the neonatal lung.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages179-194
Number of pages16
Volume967
DOIs
StatePublished - 2017

Publication series

NameAdvances in Experimental Medicine and Biology
Volume967
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Fingerprint

Hyperoxia
Oxidation-Reduction
Lung
Bronchopulmonary Dysplasia
Respiratory Sounds
Pulmonary Hypertension
Premature Infants
Lung Diseases
Blood Vessels
Asthma
Oxygen
Growth

Keywords

  • Alveologenesis
  • Heme oxygenase-1
  • Hyperoxia
  • Hypoxia inducible factor nitric oxide
  • Lung development
  • Nuclear factor E2-related factor 2
  • Pulmonary vasculogenesis redox signaling
  • Soluble guanylate cyclase
  • Vascular endothelial growth factor

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Pabelick, C. M., Thompson, M. A., & Britt, R. J. (2017). Effects of hyperoxia on the developing airway and pulmonary vasculature. In Advances in Experimental Medicine and Biology (Vol. 967, pp. 179-194). (Advances in Experimental Medicine and Biology; Vol. 967). Springer New York LLC. https://doi.org/10.1007/978-3-319-63245-2_11

Effects of hyperoxia on the developing airway and pulmonary vasculature. / Pabelick, Christina M; Thompson, Michael A.; Britt, Rodney Jr.

Advances in Experimental Medicine and Biology. Vol. 967 Springer New York LLC, 2017. p. 179-194 (Advances in Experimental Medicine and Biology; Vol. 967).

Research output: Chapter in Book/Report/Conference proceedingChapter

Pabelick, CM, Thompson, MA & Britt, RJ 2017, Effects of hyperoxia on the developing airway and pulmonary vasculature. in Advances in Experimental Medicine and Biology. vol. 967, Advances in Experimental Medicine and Biology, vol. 967, Springer New York LLC, pp. 179-194. https://doi.org/10.1007/978-3-319-63245-2_11
Pabelick CM, Thompson MA, Britt RJ. Effects of hyperoxia on the developing airway and pulmonary vasculature. In Advances in Experimental Medicine and Biology. Vol. 967. Springer New York LLC. 2017. p. 179-194. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-3-319-63245-2_11
Pabelick, Christina M ; Thompson, Michael A. ; Britt, Rodney Jr. / Effects of hyperoxia on the developing airway and pulmonary vasculature. Advances in Experimental Medicine and Biology. Vol. 967 Springer New York LLC, 2017. pp. 179-194 (Advances in Experimental Medicine and Biology).
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