Effects of healthy aging on the cardiopulmonary hemodynamic response to exercise

Vanessa P M Van Empel, David M. Kaye, Barry A Borlaug

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

This study aimed to define the influence of healthy aging on the central hemodynamic response to exercise. Advancing age results in numerous alterations to the cardiovascular system and is a major risk factor to develop heart failure. In patients with suspected heart failure with preserved ejection fraction, there is an increasing interest in the incorporation of stress hemodynamic studies into the diagnostic evaluation pathway. However, many patients with suspected heart failure with preserved ejection fraction are older, and there are few data regarding the effect of aging on the normal central hemodynamic responses to exercise. Therefore, we examined 55 healthy patients using right-sided cardiac catheterization with exercise. Mean age was 49.6 years, with 36% older than 55 years. On exercise, the mean pulmonary artery pressure was higher with advancing age (r = 0.412, p = 0.002). Additionally, age was negatively associated with cardiac index (r = 0.407, p = 0.005). The exercise-induced rise in pulmonary capillary wedge pressure (r = 0.378, p = 0.004) was greater with advancing age. Pulse pressure measured during exercise (r = 0.541, p <0.01) increased with age, as did diastolic dysfunction assessed by E/A ratio (r = 0.569, p <0.001). In conclusion, aging was associated with decreased cardiac output and increased pulmonary artery pressure during exercise, which developed as the consequence of both increased pulmonary vasculature resistance and higher left ventricular filling pressures.

Original languageEnglish (US)
Pages (from-to)131-135
Number of pages5
JournalAmerican Journal of Cardiology
Volume114
Issue number1
DOIs
StatePublished - Jul 1 2014

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Hemodynamics
Exercise
Heart Failure
Pulmonary Artery
Pressure
Pulmonary Wedge Pressure
Patient Rights
Ventricular Pressure
Cardiac Catheterization
Cardiovascular System
Cardiac Output
Blood Pressure
Lung

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Effects of healthy aging on the cardiopulmonary hemodynamic response to exercise. / Van Empel, Vanessa P M; Kaye, David M.; Borlaug, Barry A.

In: American Journal of Cardiology, Vol. 114, No. 1, 01.07.2014, p. 131-135.

Research output: Contribution to journalArticle

Van Empel, Vanessa P M ; Kaye, David M. ; Borlaug, Barry A. / Effects of healthy aging on the cardiopulmonary hemodynamic response to exercise. In: American Journal of Cardiology. 2014 ; Vol. 114, No. 1. pp. 131-135.
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