Effects of growth hormone, glucose and insulin on the factor VIII complex

G. D.O. Lowe, S. M. Middleton, I. D. Hay, G. H. Beastall, M. Singaraveloo, H. N. Cohen, J. A. Thomson, C. D. Forbes, C. R.M. Prentice

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6 Scopus citations

Abstract

The relationship of growth hormone (GH) to the factor VIII complex (VIIIC, VIIIRAg and VIIIRRCo) was investigated. No correlation between basal levels of GH and factor VIII assays was found in 23 subjects. No significant change in factor VIII assays was observed after GH suppression by oral glucose or bromocriptine. After insulin-induced hypoglycaemia all three factor VIII assays rose and fell in parallel with GH. However, after exercise the rise in VIIIC and VIIIRAg preceded the rise in GH; and no changes in factor VIII assays were observed after administration of thyrotrophin releasing hormone (TRH) (releasing endogenous GH) or exogenous GH. These findings do not support a role for GH in the regulation of plasma levels of VIIIC, VIIIRAg or VIIIRRCo.

Original languageEnglish (US)
Pages (from-to)201-211
Number of pages11
JournalThrombosis research
Volume28
Issue number2
DOIs
StatePublished - Oct 15 1982

Keywords

  • Factor VIII
  • diabetes
  • growth hormone
  • insulin

ASJC Scopus subject areas

  • Hematology

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    Lowe, G. D. O., Middleton, S. M., Hay, I. D., Beastall, G. H., Singaraveloo, M., Cohen, H. N., Thomson, J. A., Forbes, C. D., & Prentice, C. R. M. (1982). Effects of growth hormone, glucose and insulin on the factor VIII complex. Thrombosis research, 28(2), 201-211. https://doi.org/10.1016/0049-3848(82)90262-6