Effects of glucocorticoids on carbohydrate metabolism

M. McMahon, J. Gerich, P. Rizza

Research output: Contribution to journalArticle

304 Citations (Scopus)

Abstract

Glucocorticoid excess can decrease glucose utilization, increase hepatic glucose production, and stimulate glucagon secretion, lipolysis, proteolysis, and gluconeogenesis. These hormones also exert a permissive effect on gluconeogenesis, glycogenolysis, and lipolysis. All of these effects are accentuated by insulin deficiency. Hypercortisolemia potentiates the actions of catecholamines and glucagon on glucose production. Glucocorticoids, as long as present in permissive amouts, appear to play a minimal role - if any - in acute glucose counterregulation but may be important in the development of stress-induced hyperglycemia.

Original languageEnglish (US)
Pages (from-to)17-30
Number of pages14
JournalDiabetes/Metabolism Reviews
Volume4
Issue number1
StatePublished - 1988

Fingerprint

Carbohydrate Metabolism
Glucocorticoids
Glucose
Gluconeogenesis
Lipolysis
Glucagon
Proteolysis
Glycogenolysis
Hyperglycemia
Catecholamines
Hormones
Insulin
Liver

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

McMahon, M., Gerich, J., & Rizza, P. (1988). Effects of glucocorticoids on carbohydrate metabolism. Diabetes/Metabolism Reviews, 4(1), 17-30.

Effects of glucocorticoids on carbohydrate metabolism. / McMahon, M.; Gerich, J.; Rizza, P.

In: Diabetes/Metabolism Reviews, Vol. 4, No. 1, 1988, p. 17-30.

Research output: Contribution to journalArticle

McMahon, M, Gerich, J & Rizza, P 1988, 'Effects of glucocorticoids on carbohydrate metabolism', Diabetes/Metabolism Reviews, vol. 4, no. 1, pp. 17-30.
McMahon, M. ; Gerich, J. ; Rizza, P. / Effects of glucocorticoids on carbohydrate metabolism. In: Diabetes/Metabolism Reviews. 1988 ; Vol. 4, No. 1. pp. 17-30.
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