Effects of gadoxetic acid on liver elasticity measurement by using magnetic resonance elastography

Utaroh Motosugi; Tomoaki Ichikawa; Hironobu Sou; Katsuhiro Sano; Ali Muhi; Richard L. Ehman; Tsutomu Araki

doi:10.1016/j.mri.2011.08.005

Effects of gadoxetic acid on liver elasticity measurement by using magnetic resonance elastography

Utaroh Motosugi, Tomoaki Ichikawa, Hironobu Sou, Katsuhiro Sano, Ali Muhi, Richard L. Ehman, Tsutomu Araki

Radiology

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

The purpose of this study was to evaluate the effect of gadoxetic acid (Gd-EOB-DTPA) on measurements of liver stiffness by using magnetic resonance elastography (MRE). In this study, 104 consecutive patients (mean age, 67.7±9.4 years) underwent MRE using a 1.5-T MR scanner equipped with a cylindrical passive driver that was placed across the right chest wall for delivering vibrations. Axial gradient-echo images, which were automatically converted to elastograms that represented stiffness (kPa), were acquired using a continuous sinusoidal vibration of 60 Hz. Two raters independently placed a region of interest on the right lobe of the liver on the elastograms obtained before and after Gd-EOB-DTPA was administered. Liver stiffness was measured using these two elastograms and compared using a paired t test and correlation analysis. No significant difference was observed in liver stiffness before and after Gd-EOB-DTPA was administered (Rater 1, P=1200; Rater 2, P=3585). The correlation coefficients were 0.986 (Rater 1) and 0.984 (Rater 2), indicating excellent correlation between the stiffness values before and after Gd-EOB-DTPA was administered. Liver stiffness measured by MRE did not differ before and after Gd-EOB-DTPA was administered.

Original language	English (US)
Pages (from-to)	128-132
Number of pages	5
Journal	Magnetic Resonance Imaging
Volume	30
Issue number	1
DOIs	https://doi.org/10.1016/j.mri.2011.08.005
State	Published - Jan 2012

Keywords

Gadoxetic acid (Gd-EOB-DTPA)
Liver cirrhosis
MR elastography

ASJC Scopus subject areas

Biophysics
Biomedical Engineering
Radiology Nuclear Medicine and imaging

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10.1016/j.mri.2011.08.005

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title = "Effects of gadoxetic acid on liver elasticity measurement by using magnetic resonance elastography",

abstract = "The purpose of this study was to evaluate the effect of gadoxetic acid (Gd-EOB-DTPA) on measurements of liver stiffness by using magnetic resonance elastography (MRE). In this study, 104 consecutive patients (mean age, 67.7±9.4 years) underwent MRE using a 1.5-T MR scanner equipped with a cylindrical passive driver that was placed across the right chest wall for delivering vibrations. Axial gradient-echo images, which were automatically converted to elastograms that represented stiffness (kPa), were acquired using a continuous sinusoidal vibration of 60 Hz. Two raters independently placed a region of interest on the right lobe of the liver on the elastograms obtained before and after Gd-EOB-DTPA was administered. Liver stiffness was measured using these two elastograms and compared using a paired t test and correlation analysis. No significant difference was observed in liver stiffness before and after Gd-EOB-DTPA was administered (Rater 1, P=1200; Rater 2, P=3585). The correlation coefficients were 0.986 (Rater 1) and 0.984 (Rater 2), indicating excellent correlation between the stiffness values before and after Gd-EOB-DTPA was administered. Liver stiffness measured by MRE did not differ before and after Gd-EOB-DTPA was administered.",

keywords = "Gadoxetic acid (Gd-EOB-DTPA), Liver cirrhosis, MR elastography",

author = "Utaroh Motosugi and Tomoaki Ichikawa and Hironobu Sou and Katsuhiro Sano and Ali Muhi and Ehman, {Richard L.} and Tsutomu Araki",

note = "Funding Information: This work was supported in part by NIH grant EB001981 . ",

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doi = "10.1016/j.mri.2011.08.005",

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AU - Motosugi, Utaroh

AU - Ichikawa, Tomoaki

AU - Sou, Hironobu

AU - Sano, Katsuhiro

AU - Muhi, Ali

AU - Ehman, Richard L.

AU - Araki, Tsutomu

N1 - Funding Information: This work was supported in part by NIH grant EB001981 .

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KW - MR elastography

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Effects of gadoxetic acid on liver elasticity measurement by using magnetic resonance elastography

Abstract

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