Effects of exercise training on forearm and calf vasodilation and proinflammatory markers in recent heart transplant recipients: A pilot study

Gary L. Pierce, Richard S. Schofield, Darren P. Casey, Scott A. Hamlin, James A. Hill, Randy W. Braith

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

BACKGROUND: Aerobic exercise training improves vasodilatory capacity of peripheral resistance vasculature and modifies plasma proinflammatory markers in chronic heart failure patients. It is, however, currently unknown whether aerobic exercise has a similar effect in heart transplant recipients (HTR). DESIGN AND METHODS: Eight weeks after transplantation, 14 HTR were randomly assigned to 12 weeks of supervised aerobic exercise training (TRAINED; n=8) or attention-time control (CONTROL; n=6) in addition to posttransplantation medical care. Peak forearm blood flow and calf blood flow (CBF) during reactive hyperemia after 5 min of limb ischemia was used as a measure of endothelium-dependent vasodilation of limb resistance arteries. Plasma C-reactive protein, interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), soluble intercellular adhesion molecule-1 (sICAM-1), and exercise capacity were measured at baseline and again after 12 weeks in both groups. RESULTS: Peak CBF increased 22% in the TRAINED (25.9±5.8-31.6±7.9 ml/min/100 ml, P<0.05), but there was no change in peak CBF after 12 weeks in CONTROL. Plasma C-reactive protein, IL-6, TNF-α, sICAM-1 did not change in TRAINED, but there was a significant increase in TNF-α (1.66±1.02 vs. 3.07±1.10 pg/ml, P<0.05), and sICAM-1 (205.9±59.1 vs. 245.0±47.9 ng/ml, P<0.01) in CONTROL after 12 weeks. Furthermore, exercise test duration improved 51.7% (P<0.01) and there was a trend toward an increase in peak VO2 (P=0.05) in TRAINED after 12 weeks but neither changed in CONTROL. CONCLUSION: A program of supervised aerobic exercise improves endothelium-dependent vasodilation of the calf, but not forearm resistance arteries, and may attenuate a progressive increase in selected proinflammatory markers in HTR.

Original languageEnglish (US)
Pages (from-to)10-18
Number of pages9
JournalEuropean Journal of Cardiovascular Prevention and Rehabilitation
Volume15
Issue number1
DOIs
StatePublished - Feb 2008
Externally publishedYes

Fingerprint

Forearm
Vasodilation
Exercise
Intercellular Adhesion Molecule-1
Tumor Necrosis Factor-alpha
C-Reactive Protein
Endothelium
Blood Proteins
Interleukin-6
Extremities
Arteries
Hyperemia
Heart Transplantation
Transplant Recipients
Exercise Test
Vascular Resistance
Ischemia
Heart Failure

Keywords

  • Endothelial-dependent vasodilation
  • Exercise
  • Heart transplantation
  • Inflammation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Public Health, Environmental and Occupational Health
  • Rehabilitation

Cite this

Effects of exercise training on forearm and calf vasodilation and proinflammatory markers in recent heart transplant recipients : A pilot study. / Pierce, Gary L.; Schofield, Richard S.; Casey, Darren P.; Hamlin, Scott A.; Hill, James A.; Braith, Randy W.

In: European Journal of Cardiovascular Prevention and Rehabilitation, Vol. 15, No. 1, 02.2008, p. 10-18.

Research output: Contribution to journalArticle

Pierce, Gary L. ; Schofield, Richard S. ; Casey, Darren P. ; Hamlin, Scott A. ; Hill, James A. ; Braith, Randy W. / Effects of exercise training on forearm and calf vasodilation and proinflammatory markers in recent heart transplant recipients : A pilot study. In: European Journal of Cardiovascular Prevention and Rehabilitation. 2008 ; Vol. 15, No. 1. pp. 10-18.
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T1 - Effects of exercise training on forearm and calf vasodilation and proinflammatory markers in recent heart transplant recipients

T2 - A pilot study

AU - Pierce, Gary L.

AU - Schofield, Richard S.

AU - Casey, Darren P.

AU - Hamlin, Scott A.

AU - Hill, James A.

AU - Braith, Randy W.

PY - 2008/2

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N2 - BACKGROUND: Aerobic exercise training improves vasodilatory capacity of peripheral resistance vasculature and modifies plasma proinflammatory markers in chronic heart failure patients. It is, however, currently unknown whether aerobic exercise has a similar effect in heart transplant recipients (HTR). DESIGN AND METHODS: Eight weeks after transplantation, 14 HTR were randomly assigned to 12 weeks of supervised aerobic exercise training (TRAINED; n=8) or attention-time control (CONTROL; n=6) in addition to posttransplantation medical care. Peak forearm blood flow and calf blood flow (CBF) during reactive hyperemia after 5 min of limb ischemia was used as a measure of endothelium-dependent vasodilation of limb resistance arteries. Plasma C-reactive protein, interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), soluble intercellular adhesion molecule-1 (sICAM-1), and exercise capacity were measured at baseline and again after 12 weeks in both groups. RESULTS: Peak CBF increased 22% in the TRAINED (25.9±5.8-31.6±7.9 ml/min/100 ml, P<0.05), but there was no change in peak CBF after 12 weeks in CONTROL. Plasma C-reactive protein, IL-6, TNF-α, sICAM-1 did not change in TRAINED, but there was a significant increase in TNF-α (1.66±1.02 vs. 3.07±1.10 pg/ml, P<0.05), and sICAM-1 (205.9±59.1 vs. 245.0±47.9 ng/ml, P<0.01) in CONTROL after 12 weeks. Furthermore, exercise test duration improved 51.7% (P<0.01) and there was a trend toward an increase in peak VO2 (P=0.05) in TRAINED after 12 weeks but neither changed in CONTROL. CONCLUSION: A program of supervised aerobic exercise improves endothelium-dependent vasodilation of the calf, but not forearm resistance arteries, and may attenuate a progressive increase in selected proinflammatory markers in HTR.

AB - BACKGROUND: Aerobic exercise training improves vasodilatory capacity of peripheral resistance vasculature and modifies plasma proinflammatory markers in chronic heart failure patients. It is, however, currently unknown whether aerobic exercise has a similar effect in heart transplant recipients (HTR). DESIGN AND METHODS: Eight weeks after transplantation, 14 HTR were randomly assigned to 12 weeks of supervised aerobic exercise training (TRAINED; n=8) or attention-time control (CONTROL; n=6) in addition to posttransplantation medical care. Peak forearm blood flow and calf blood flow (CBF) during reactive hyperemia after 5 min of limb ischemia was used as a measure of endothelium-dependent vasodilation of limb resistance arteries. Plasma C-reactive protein, interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), soluble intercellular adhesion molecule-1 (sICAM-1), and exercise capacity were measured at baseline and again after 12 weeks in both groups. RESULTS: Peak CBF increased 22% in the TRAINED (25.9±5.8-31.6±7.9 ml/min/100 ml, P<0.05), but there was no change in peak CBF after 12 weeks in CONTROL. Plasma C-reactive protein, IL-6, TNF-α, sICAM-1 did not change in TRAINED, but there was a significant increase in TNF-α (1.66±1.02 vs. 3.07±1.10 pg/ml, P<0.05), and sICAM-1 (205.9±59.1 vs. 245.0±47.9 ng/ml, P<0.01) in CONTROL after 12 weeks. Furthermore, exercise test duration improved 51.7% (P<0.01) and there was a trend toward an increase in peak VO2 (P=0.05) in TRAINED after 12 weeks but neither changed in CONTROL. CONCLUSION: A program of supervised aerobic exercise improves endothelium-dependent vasodilation of the calf, but not forearm resistance arteries, and may attenuate a progressive increase in selected proinflammatory markers in HTR.

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