Effects of exercise and weight loss on leucine turnover in different types of obesity

J. A. Kanaley, M. W. Haymond, Michael Dennis Jensen

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

These studies were performed to determine whether protein turnover during exercise and after weight loss is influenced by obesity and body fat distribution. Leucine carbon flux was measured before, during, and after 2.5 h of bicycle exercise in 10 upper body obese, 9 lower body obese, and 6 nonobese, age-matched, premenopausal women. The obese women then followed an energy-restricted diet for 16 wk, resulting in ~8 kg weight loss. Baseline leucine carbon flux was greater (P < 0.01) in obese women than in nonobese women but decreased in a similar fashion in response to exercise in all groups. There were no differences between upper body and lower body obese women during exercise. After weight loss, baseline leucine carbon flux decreased (P < 0.05) similarly in both groups of obese women and was further suppressed by exercise. Thus obesity phenotype has no specific effect on either baseline protein turnover or the antiproteolytic response to moderate intensity exercise or weight loss. We conclude that the previously observed defect in insulin suppression of leucine flux in upper body obese women appears related to insulin resistance and does not represent an inherent abnormality of protein metabolism.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Endocrinology and Metabolism
Volume264
Issue number5 27-5
StatePublished - 1993

Fingerprint

Leucine
Weight Loss
Obesity
Exercise
Fluxes
Carbon
Carbon Cycle
Insulin
Exercise equipment
Proteins
Nutrition
Metabolism
Body Fat Distribution
Fats
Defects
Insulin Resistance
Diet
Phenotype

Keywords

  • amino acid flux
  • hyperinsulinemia
  • insulin
  • proteolysis

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology

Cite this

Effects of exercise and weight loss on leucine turnover in different types of obesity. / Kanaley, J. A.; Haymond, M. W.; Jensen, Michael Dennis.

In: American Journal of Physiology - Endocrinology and Metabolism, Vol. 264, No. 5 27-5, 1993.

Research output: Contribution to journalArticle

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