Effects of ethyl alcohol on canine jejunal circular smooth muscle

Gang Lu, Michael G. Sarr, Joseph H. Szurszewski

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Ethyl alcohol has many symptomatic effects on the gastrointestinal tract. Our aim was to determine the effects of ethyl alcohol on circular smooth muscle contractility of the canine small bowel. Mechanical and intracellular electrical recordings were made in vitro from the circular muscle of full-thickness strips of muscularis externa from canine jejunum. Ethyl alcohol (20-120 mM) dose-dependently decreased spontaneous contractile amplitude, hyperpolarized the resting membrane potential, and decreased the amplitude of the slow wave. Ethyl alcohol also decreased the amplitude of the inhibitory junction potential (during electrical field stimulation-EFS) but did not alter the maximum absolute cell-polarized potential reached during EFS. An increase in extracellular calcium (15 mM) partially restored spontaneous contractile amplitude, resting membrane potential, and slow-wave amplitude. Ethyl alcohol decreased the amplitude of contractions evoked by acetylcholine, CCK, and substance P. These data suggest that ethyl alcohol has direct effects on jejunal smooth muscle contractility. These effects can be partially reversed by increasing the availability of extracellular calcium.

Original languageEnglish (US)
Pages (from-to)2403-2410
Number of pages8
JournalDigestive Diseases and Sciences
Volume42
Issue number12
DOIs
StatePublished - 1997
Externally publishedYes

Fingerprint

Smooth Muscle
Canidae
Ethanol
Membrane Potentials
Calcium
Jejunum
Substance P
Electric Stimulation
Acetylcholine
Gastrointestinal Tract
Muscles

Keywords

  • CCK
  • Electrical field stimulation
  • Ethyl alcohol
  • Intestinal motility
  • Smooth muscle contraction
  • Substance P

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Effects of ethyl alcohol on canine jejunal circular smooth muscle. / Lu, Gang; Sarr, Michael G.; Szurszewski, Joseph H.

In: Digestive Diseases and Sciences, Vol. 42, No. 12, 1997, p. 2403-2410.

Research output: Contribution to journalArticle

Lu, Gang ; Sarr, Michael G. ; Szurszewski, Joseph H. / Effects of ethyl alcohol on canine jejunal circular smooth muscle. In: Digestive Diseases and Sciences. 1997 ; Vol. 42, No. 12. pp. 2403-2410.
@article{ebd80b73aba64605809b3b8d3d48d231,
title = "Effects of ethyl alcohol on canine jejunal circular smooth muscle",
abstract = "Ethyl alcohol has many symptomatic effects on the gastrointestinal tract. Our aim was to determine the effects of ethyl alcohol on circular smooth muscle contractility of the canine small bowel. Mechanical and intracellular electrical recordings were made in vitro from the circular muscle of full-thickness strips of muscularis externa from canine jejunum. Ethyl alcohol (20-120 mM) dose-dependently decreased spontaneous contractile amplitude, hyperpolarized the resting membrane potential, and decreased the amplitude of the slow wave. Ethyl alcohol also decreased the amplitude of the inhibitory junction potential (during electrical field stimulation-EFS) but did not alter the maximum absolute cell-polarized potential reached during EFS. An increase in extracellular calcium (15 mM) partially restored spontaneous contractile amplitude, resting membrane potential, and slow-wave amplitude. Ethyl alcohol decreased the amplitude of contractions evoked by acetylcholine, CCK, and substance P. These data suggest that ethyl alcohol has direct effects on jejunal smooth muscle contractility. These effects can be partially reversed by increasing the availability of extracellular calcium.",
keywords = "CCK, Electrical field stimulation, Ethyl alcohol, Intestinal motility, Smooth muscle contraction, Substance P",
author = "Gang Lu and Sarr, {Michael G.} and Szurszewski, {Joseph H.}",
year = "1997",
doi = "10.1023/A:1018827604434",
language = "English (US)",
volume = "42",
pages = "2403--2410",
journal = "Digestive Diseases and Sciences",
issn = "0163-2116",
publisher = "Springer New York",
number = "12",

}

TY - JOUR

T1 - Effects of ethyl alcohol on canine jejunal circular smooth muscle

AU - Lu, Gang

AU - Sarr, Michael G.

AU - Szurszewski, Joseph H.

PY - 1997

Y1 - 1997

N2 - Ethyl alcohol has many symptomatic effects on the gastrointestinal tract. Our aim was to determine the effects of ethyl alcohol on circular smooth muscle contractility of the canine small bowel. Mechanical and intracellular electrical recordings were made in vitro from the circular muscle of full-thickness strips of muscularis externa from canine jejunum. Ethyl alcohol (20-120 mM) dose-dependently decreased spontaneous contractile amplitude, hyperpolarized the resting membrane potential, and decreased the amplitude of the slow wave. Ethyl alcohol also decreased the amplitude of the inhibitory junction potential (during electrical field stimulation-EFS) but did not alter the maximum absolute cell-polarized potential reached during EFS. An increase in extracellular calcium (15 mM) partially restored spontaneous contractile amplitude, resting membrane potential, and slow-wave amplitude. Ethyl alcohol decreased the amplitude of contractions evoked by acetylcholine, CCK, and substance P. These data suggest that ethyl alcohol has direct effects on jejunal smooth muscle contractility. These effects can be partially reversed by increasing the availability of extracellular calcium.

AB - Ethyl alcohol has many symptomatic effects on the gastrointestinal tract. Our aim was to determine the effects of ethyl alcohol on circular smooth muscle contractility of the canine small bowel. Mechanical and intracellular electrical recordings were made in vitro from the circular muscle of full-thickness strips of muscularis externa from canine jejunum. Ethyl alcohol (20-120 mM) dose-dependently decreased spontaneous contractile amplitude, hyperpolarized the resting membrane potential, and decreased the amplitude of the slow wave. Ethyl alcohol also decreased the amplitude of the inhibitory junction potential (during electrical field stimulation-EFS) but did not alter the maximum absolute cell-polarized potential reached during EFS. An increase in extracellular calcium (15 mM) partially restored spontaneous contractile amplitude, resting membrane potential, and slow-wave amplitude. Ethyl alcohol decreased the amplitude of contractions evoked by acetylcholine, CCK, and substance P. These data suggest that ethyl alcohol has direct effects on jejunal smooth muscle contractility. These effects can be partially reversed by increasing the availability of extracellular calcium.

KW - CCK

KW - Electrical field stimulation

KW - Ethyl alcohol

KW - Intestinal motility

KW - Smooth muscle contraction

KW - Substance P

UR - http://www.scopus.com/inward/record.url?scp=0031409234&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031409234&partnerID=8YFLogxK

U2 - 10.1023/A:1018827604434

DO - 10.1023/A:1018827604434

M3 - Article

C2 - 9440612

AN - SCOPUS:0031409234

VL - 42

SP - 2403

EP - 2410

JO - Digestive Diseases and Sciences

JF - Digestive Diseases and Sciences

SN - 0163-2116

IS - 12

ER -