Effects of erythromycin on gut transit in pseudo-obstruction due to hereditary coproporphyria

Mario J. Vassallo, Michael Camilleri, Stephen N. Sullivan, George M. Thomforde

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

We studied gastrointestinal transit in a 57-year-old man with chronic intestinal pseudo-obstruction along with peripheral and autonomic neuropathy due to hereditary coproporphyria and we evaluated the effects of acute and chronic therapy with erythromycin. Noninvasive scintigraphic studies of regional transit of solid residue through the gut were obtained before treatment, during the acute i.v. administration of 500 mg, every-8-h doses of erythromycin for 24 h and after 15 weeks of oral therapy (500 mg, three times daily). During acute i.v. administration, symptoms and transit measurements dramatically improved; however, all parameters and symptoms returned to pretreatment levels during chronic oral therapy. We conclude that hereditary coproporphyria with associated autonomic neuropathy results in significant delay in small bowel and colonic transit; chronic administration of 500 mg three times a day oral erythromycin was not associated with maintenance of the improvement in regional transit and symptoms observed following acute i.v. administration of the drug at the same dose.

Original languageEnglish (US)
Pages (from-to)255-259
Number of pages5
JournalJournal of Clinical Gastroenterology
Volume14
Issue number3
StatePublished - 1992

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Hereditary Coproporphyria
Erythromycin
Gastrointestinal Transit
Intestinal Pseudo-Obstruction
Peripheral Nervous System Diseases
Therapeutics
Maintenance
Pharmaceutical Preparations

Keywords

  • Autonomic neuropathy
  • Erythromycin
  • Motility
  • Porphyria
  • Transit

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Effects of erythromycin on gut transit in pseudo-obstruction due to hereditary coproporphyria. / Vassallo, Mario J.; Camilleri, Michael; Sullivan, Stephen N.; Thomforde, George M.

In: Journal of Clinical Gastroenterology, Vol. 14, No. 3, 1992, p. 255-259.

Research output: Contribution to journalArticle

Vassallo, Mario J. ; Camilleri, Michael ; Sullivan, Stephen N. ; Thomforde, George M. / Effects of erythromycin on gut transit in pseudo-obstruction due to hereditary coproporphyria. In: Journal of Clinical Gastroenterology. 1992 ; Vol. 14, No. 3. pp. 255-259.
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