TY - JOUR
T1 - Effects of endurance training on baroreflex sensitivity and blood pressure in borderline hypertension
AU - Somers, V. K.
AU - Conway, J.
AU - Johnston, J.
AU - Sleight, P.
PY - 1991/6/8
Y1 - 1991/6/8
N2 - Physical training offers a potential non-pharmacological strategy for control of mild and borderline hypertension, but its effect on blood pressure is controversial. We investigated the effects of endurance training on waking and sleeping blood pressure and on baroreflex sensitivity in 16 borderline hypertensive patients. First, 8 patients were assessed before and after a 6-month endurance training programme. Then, when it was clear that blood pressures were lower after training, a further 8 patients were studied not only at the end of the training programme but also after 4 months' abstention from exercise (detraining). Measurements were taken of baroreflex sensitivity (response to iv phenylephrine), blood pressure, R-R interval, and blood pressure and R-R variability. Ambulatory blood pressures were measured in 13 patients (7 trained, 6 detrained) and sleep blood pressures in 6 patients (3 trained, 3 detrained). Increased fitness was associated with a decline in resting arterial blood pressure of 9·7 (SE 2·0) mm Hg systolic and 6·8 (1·2) mm Hg diastolic, and with a decline in ambulatory blood pressure of 4·8 (1·4) mm Hg and 7·5 (2·1) mm Hg, respectively; both p<0·05. Baroreflex sensitivity was 14·0 (1·8) ms/mm Hg in the unfit and 17·5 (2·0) ms/mm Hg in the fit; p < 0·05. Sleep blood pressures were not lower in the fit despite longer sleep R-R intervals. These findings indicate that, in some subjects with borderline or mild hypertension, a physical training programme is sufficient to bring the blood pressure within normal limits.
AB - Physical training offers a potential non-pharmacological strategy for control of mild and borderline hypertension, but its effect on blood pressure is controversial. We investigated the effects of endurance training on waking and sleeping blood pressure and on baroreflex sensitivity in 16 borderline hypertensive patients. First, 8 patients were assessed before and after a 6-month endurance training programme. Then, when it was clear that blood pressures were lower after training, a further 8 patients were studied not only at the end of the training programme but also after 4 months' abstention from exercise (detraining). Measurements were taken of baroreflex sensitivity (response to iv phenylephrine), blood pressure, R-R interval, and blood pressure and R-R variability. Ambulatory blood pressures were measured in 13 patients (7 trained, 6 detrained) and sleep blood pressures in 6 patients (3 trained, 3 detrained). Increased fitness was associated with a decline in resting arterial blood pressure of 9·7 (SE 2·0) mm Hg systolic and 6·8 (1·2) mm Hg diastolic, and with a decline in ambulatory blood pressure of 4·8 (1·4) mm Hg and 7·5 (2·1) mm Hg, respectively; both p<0·05. Baroreflex sensitivity was 14·0 (1·8) ms/mm Hg in the unfit and 17·5 (2·0) ms/mm Hg in the fit; p < 0·05. Sleep blood pressures were not lower in the fit despite longer sleep R-R intervals. These findings indicate that, in some subjects with borderline or mild hypertension, a physical training programme is sufficient to bring the blood pressure within normal limits.
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U2 - 10.1016/0140-6736(91)93056-F
DO - 10.1016/0140-6736(91)93056-F
M3 - Article
C2 - 1674761
AN - SCOPUS:0025774558
SN - 0140-6736
VL - 337
SP - 1363
EP - 1368
JO - The Lancet
JF - The Lancet
IS - 8754
ER -