Effects of elevated gonadotropin levels on thyroid function in the male rat

R. W. Steger, V. Chandrashekar, A. Bartke, J. Wortsman, S. C. Newton, Robert Christian Smallridge, J. Dietrich

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

In order to determine if thyroid disease in hypogonadal men is the result of chronic elevation of serum gonadotropins, thyroid histology and serum thyroid hormone levels were evaluated in male rats that had been castrated either 2 weeks or 15 months previously. Despite significantly elevating serum LH levels, castration did not affect thyroid structure or function. Serum total T4 levels were reduced with age in both short and long-term castrate animals but returned to the levels seen in young rats when testosterone was replaced. Testosterone replacement also increased free T4 levels in both the young and old castrate rats. Neither age nor testosterone replacement affected serum T3 or TSH levels.

Original languageEnglish (US)
Pages (from-to)85-90
Number of pages6
JournalLife Sciences
Volume45
Issue number1
DOIs
StatePublished - 1989
Externally publishedYes

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Gonadotropins
Testosterone
Rats
Thyroid Gland
Serum
Histology
Thyroid Hormones
Animals
Castration
Thyroid Diseases

ASJC Scopus subject areas

  • Pharmacology

Cite this

Steger, R. W., Chandrashekar, V., Bartke, A., Wortsman, J., Newton, S. C., Smallridge, R. C., & Dietrich, J. (1989). Effects of elevated gonadotropin levels on thyroid function in the male rat. Life Sciences, 45(1), 85-90. https://doi.org/10.1016/0024-3205(89)90439-6

Effects of elevated gonadotropin levels on thyroid function in the male rat. / Steger, R. W.; Chandrashekar, V.; Bartke, A.; Wortsman, J.; Newton, S. C.; Smallridge, Robert Christian; Dietrich, J.

In: Life Sciences, Vol. 45, No. 1, 1989, p. 85-90.

Research output: Contribution to journalArticle

Steger, RW, Chandrashekar, V, Bartke, A, Wortsman, J, Newton, SC, Smallridge, RC & Dietrich, J 1989, 'Effects of elevated gonadotropin levels on thyroid function in the male rat', Life Sciences, vol. 45, no. 1, pp. 85-90. https://doi.org/10.1016/0024-3205(89)90439-6
Steger, R. W. ; Chandrashekar, V. ; Bartke, A. ; Wortsman, J. ; Newton, S. C. ; Smallridge, Robert Christian ; Dietrich, J. / Effects of elevated gonadotropin levels on thyroid function in the male rat. In: Life Sciences. 1989 ; Vol. 45, No. 1. pp. 85-90.
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