Effects of deforming stress on the apparent stiffness of alveolar epithelial cells

Rolf D. Hubmayr, Mark A. Schroeder, Timothy A. Baker, Ben Fabry, Bruce J. Walters

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

A study was carried out to compare the apparent stiffness of A549 cells before and after removal of loosely bound bends with centrifugation. It was found that heterogeneous bead behavior produce substantial bias in average cell stiffness, even when large bead torque are applied. The lack of a cell stiffening response during and after repeated twists suggests that deforming stresses do not strengthen the mechanical linkage between cells and beads and do not induce contraction of stress fibers in the A549 alveolar epithelial cell model system.

Original languageEnglish (US)
Title of host publicationAmerican Society of Mechanical Engineers, Bioengineering Division (Publication) BED
Place of PublicationFairfield, NJ, United States
PublisherASME
Pages519-520
Number of pages2
Volume42
ISBN (Print)0791816117
StatePublished - 1999
Event1999 Bioengineering Conference - Big Sky, MT, USA
Duration: Jun 16 1999Jun 20 1999

Other

Other1999 Bioengineering Conference
CityBig Sky, MT, USA
Period6/16/996/20/99

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ASJC Scopus subject areas

  • Engineering(all)

Cite this

Hubmayr, R. D., Schroeder, M. A., Baker, T. A., Fabry, B., & Walters, B. J. (1999). Effects of deforming stress on the apparent stiffness of alveolar epithelial cells. In American Society of Mechanical Engineers, Bioengineering Division (Publication) BED (Vol. 42, pp. 519-520). ASME.