Effects of deforming stress on the apparent stiffness of alveolar epithelial cells

Rolf D. Hubmayr; Mark A. Schroeder; Timothy A. Baker; Ben Fabry; Bruce J. Walters

Effects of deforming stress on the apparent stiffness of alveolar epithelial cells

Rolf D. Hubmayr, Mark A. Schroeder, Timothy A. Baker, Ben Fabry, Bruce J. Walters

Pulmonary and Critical Care Medicine

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

A study was carried out to compare the apparent stiffness of A549 cells before and after removal of loosely bound bends with centrifugation. It was found that heterogeneous bead behavior produce substantial bias in average cell stiffness, even when large bead torque are applied. The lack of a cell stiffening response during and after repeated twists suggests that deforming stresses do not strengthen the mechanical linkage between cells and beads and do not induce contraction of stress fibers in the A549 alveolar epithelial cell model system.

Original language	English (US)
Title of host publication	American Society of Mechanical Engineers, Bioengineering Division (Publication) BED
Publisher	ASME
Pages	519-520
Number of pages	2
Volume	42
ISBN (Print)	0791816117
State	Published - Dec 1 1999
Event	1999 Bioengineering Conference - Big Sky, MT, USA Duration: Jun 16 1999 → Jun 20 1999

Other

Other	1999 Bioengineering Conference
City	Big Sky, MT, USA
Period	6/16/99 → 6/20/99

ASJC Scopus subject areas

Engineering(all)

Cite this

Effects of deforming stress on the apparent stiffness of alveolar epithelial cells. / Hubmayr, Rolf D.; Schroeder, Mark A.; Baker, Timothy A.; Fabry, Ben; Walters, Bruce J.

American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. Vol. 42 ASME, 1999. p. 519-520.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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AU - Baker, Timothy A.

AU - Fabry, Ben

AU - Walters, Bruce J.

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N2 - A study was carried out to compare the apparent stiffness of A549 cells before and after removal of loosely bound bends with centrifugation. It was found that heterogeneous bead behavior produce substantial bias in average cell stiffness, even when large bead torque are applied. The lack of a cell stiffening response during and after repeated twists suggests that deforming stresses do not strengthen the mechanical linkage between cells and beads and do not induce contraction of stress fibers in the A549 alveolar epithelial cell model system.

AB - A study was carried out to compare the apparent stiffness of A549 cells before and after removal of loosely bound bends with centrifugation. It was found that heterogeneous bead behavior produce substantial bias in average cell stiffness, even when large bead torque are applied. The lack of a cell stiffening response during and after repeated twists suggests that deforming stresses do not strengthen the mechanical linkage between cells and beads and do not induce contraction of stress fibers in the A549 alveolar epithelial cell model system.

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T2 - 1999 Bioengineering Conference

Y2 - 16 June 1999 through 20 June 1999

ER -

Effects of deforming stress on the apparent stiffness of alveolar epithelial cells

Abstract

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ASJC Scopus subject areas

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