Effects of Central Obesity on Esophageal Epithelial Barrier Function

Ying Y. Gibbens; Ramona Lansing; Michele L. Johnson; Christopher H. Blevins; David A. Katzka; Prasad G. Iyer

doi:10.14309/ajg.0000000000001196

Effects of Central Obesity on Esophageal Epithelial Barrier Function

Ying Y. Gibbens, Ramona Lansing, Michele L. Johnson, Christopher H. Blevins, David A. Katzka, Prasad G. Iyer

Gastroenterology and Hepatology

Research output: Contribution to journal › Article › peer-review

Abstract

INTRODUCTION:We assessed if obesity perturbs the esophageal epithelial barrier function independent of promotion of gastroesophageal reflux (GER).METHODS:Thirty-eight participants were divided into 4 groups: Obesity-/GER-, Obesity+/GER-, Obesity-/GER+, and Obesity+/GER+. Esophageal intercellular space and desmosome density (structural integrity) and fluorescein leak (functional integrity) were measured.RESULTS:The Obesity+/GER- group demonstrated increased intercellular space, reduced desmosome density, and increased fluorescein leak compared with control subjects. These changes were similar but not additive to findings seen in Obesity-/GER + and Obesity+/GER+ patients.DISCUSSION:Central obesity impairs structural and functional integrity of the esophageal barrier independent of GER, likely predisposing to esophageal injury.

Original language	English (US)
Pages (from-to)	1537-1541
Number of pages	5
Journal	American Journal of Gastroenterology
Volume	116
Issue number	7
DOIs	https://doi.org/10.14309/ajg.0000000000001196
State	Published - Jul 1 2021

ASJC Scopus subject areas

Hepatology
Gastroenterology

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title = "Effects of Central Obesity on Esophageal Epithelial Barrier Function",

abstract = "INTRODUCTION:We assessed if obesity perturbs the esophageal epithelial barrier function independent of promotion of gastroesophageal reflux (GER).METHODS:Thirty-eight participants were divided into 4 groups: Obesity-/GER-, Obesity+/GER-, Obesity-/GER+, and Obesity+/GER+. Esophageal intercellular space and desmosome density (structural integrity) and fluorescein leak (functional integrity) were measured.RESULTS:The Obesity+/GER- group demonstrated increased intercellular space, reduced desmosome density, and increased fluorescein leak compared with control subjects. These changes were similar but not additive to findings seen in Obesity-/GER + and Obesity+/GER+ patients.DISCUSSION:Central obesity impairs structural and functional integrity of the esophageal barrier independent of GER, likely predisposing to esophageal injury.",

author = "Gibbens, {Ying Y.} and Ramona Lansing and Johnson, {Michele L.} and Blevins, {Christopher H.} and Katzka, {David A.} and Iyer, {Prasad G.}",

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T1 - Effects of Central Obesity on Esophageal Epithelial Barrier Function

AU - Gibbens, Ying Y.

AU - Lansing, Ramona

AU - Johnson, Michele L.

AU - Blevins, Christopher H.

AU - Katzka, David A.

AU - Iyer, Prasad G.

PY - 2021/7/1

Y1 - 2021/7/1

N2 - INTRODUCTION:We assessed if obesity perturbs the esophageal epithelial barrier function independent of promotion of gastroesophageal reflux (GER).METHODS:Thirty-eight participants were divided into 4 groups: Obesity-/GER-, Obesity+/GER-, Obesity-/GER+, and Obesity+/GER+. Esophageal intercellular space and desmosome density (structural integrity) and fluorescein leak (functional integrity) were measured.RESULTS:The Obesity+/GER- group demonstrated increased intercellular space, reduced desmosome density, and increased fluorescein leak compared with control subjects. These changes were similar but not additive to findings seen in Obesity-/GER + and Obesity+/GER+ patients.DISCUSSION:Central obesity impairs structural and functional integrity of the esophageal barrier independent of GER, likely predisposing to esophageal injury.

AB - INTRODUCTION:We assessed if obesity perturbs the esophageal epithelial barrier function independent of promotion of gastroesophageal reflux (GER).METHODS:Thirty-eight participants were divided into 4 groups: Obesity-/GER-, Obesity+/GER-, Obesity-/GER+, and Obesity+/GER+. Esophageal intercellular space and desmosome density (structural integrity) and fluorescein leak (functional integrity) were measured.RESULTS:The Obesity+/GER- group demonstrated increased intercellular space, reduced desmosome density, and increased fluorescein leak compared with control subjects. These changes were similar but not additive to findings seen in Obesity-/GER + and Obesity+/GER+ patients.DISCUSSION:Central obesity impairs structural and functional integrity of the esophageal barrier independent of GER, likely predisposing to esophageal injury.

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Effects of Central Obesity on Esophageal Epithelial Barrier Function

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