Effects of cardioselective and nonselective beta-adrenergic blockade on the performance of highly trained runners

Richard L. Anderson, Jack H. Wilmore, Michael J. Joyner, Beau J. Freund, Albert A. Hartzell, Carl A. Todd, Gordon A. Ewy

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

Twenty-five highly trained runners with a maximal oxygen uptake (V02 Max) of 64.7 ± 4.3 mi · kg-1 · min-1 were administered clinically equivalent doses of a nonselective (propranolol) and a cardioselective (atenolol) β-blocking agent as well as a placebo. The subjects performed a horizontal treadmill test on the eighth day and a 10-km track race on the tenth day of each treatment. Beta blockade decreased submaximal heart rate and propranolol caused the largest decrease. Beta blockade caused a decrease in maximal heart rate, V02 Max, maximal ventilation, maximal respiratory exchange ratio and treadmill time. Propranolol caused a greater decrease than atenolol in each of these values. The 10-km race times were significantly slower during β blockade, and propranolol race times were significantly slower than atenolol race times. It is concluded that the performance of highly trained distance runners is significantly altered by β-adrenergic blockade and that nonselective agents reduce performance to a greater extent than cardioselective agents.

Original languageEnglish (US)
Pages (from-to)D149-D154
JournalThe American journal of cardiology
Volume55
Issue number10
DOIs
StatePublished - Apr 26 1985

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Effects of cardioselective and nonselective beta-adrenergic blockade on the performance of highly trained runners'. Together they form a unique fingerprint.

  • Cite this