Effects of cadmium on the kinetics of calcium uptake in developing tilapia larvae, Oreochromis mossambicus

M. H. Chang, H. C. Lin, P. P. Hwang

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

The toxic effects of Cd2+ on Ca2+ influx kinetics in developing tilapia (Oreochromis mossambicus) larvae were evaluated. Addition of 20 μg l-1 of Cd2+ to the environment of 0 and 3 day-old larvae competitively inhibited the Ca2+ uptake within 4h resulting in a great increase in Km values for Ca2+ influx (19.3 and 17.4 fold, respectively) as compared with their respective controls. Consequently, the actual Ca2+ influx of larvae in solutions of 0.2 mM Ca2+ are suppressed by 32-45%. Also, 3 day-old larvae were more sensitive to internally accumulated Cd2+ than 0 day-old larvae. Although the Ca2+ influx in 0 and 3 day-old larvae may be restored to the levels of their respective controls with 24h of being transferred to a 20 μg l-1 Cd2+ solution, total body Ca2+ content was significantly reduced in 3 day-old larvae. Increased Ca2+ uptake efficiency ensures sufficient Ca2+ for normal growth. However, rapid increase in Ca2+ influx after hatching also leads to higher Cd2+ uptake. Exposure to Cd2+ will lead to a drop in body Ca2+ content resulting in retardation of larval growth. Therefore, we conclude that if Ca2+ uptake is interfered with at this critical stage of development, larvae will not be able to maintain normal levels of body Ca2+ and will show signs of Cd2+ poisoning.

Original languageEnglish (US)
Pages (from-to)459-470
Number of pages12
JournalFish Physiology and Biochemistry
Volume16
Issue number6
DOIs
StatePublished - Jan 1 1997

Keywords

  • Ca influx
  • Cadmium
  • Calcium
  • Development
  • K
  • Larvae
  • Tilapia
  • Toxicity
  • V

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Aquatic Science

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