Effects of bradykinin on renal interstitial pressures and proximal tubule reabsorption.

J. I. Mertz, J. A. Haas, T. J. Berndt, John C Jr. Burnett, F. G. Knox

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8 Citations (Scopus)

Abstract

Renal interstitial Starling forces have been postulated as the link between the peritubular microcirculation and fluid reabsorption by the proximal tubule. The renal vasodilator bradykinin was used as a tool to test this relationship in micropuncture studies in the rat. Bradykinin increased peritubular capillary and interstitial hydrostatic pressures and decreased peritubular and interstitial oncotic pressures. The balance of Starling forces in the interstitium (interstitial oncotic pressure minus interstitial hydrostatic pressure) was significantly decreased from 6.5 +/- 2.3 to -4.0 +/- 1.3 mmHg without a change in fluid reabsorption by the proximal tubule. We conclude that renal interstitial Starling forces do not regulate reabsorption by the superficial proximal tubule in the rat in response to bradykinin.

Original languageEnglish (US)
JournalThe American journal of physiology
Volume247
Issue number1 Pt 2
StatePublished - Jul 1984

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Starlings
Bradykinin
Hydrostatic Pressure
Kidney
Pressure
Microcirculation
Vasodilator Agents
Punctures
Renal Reabsorption

ASJC Scopus subject areas

  • Medicine(all)

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Effects of bradykinin on renal interstitial pressures and proximal tubule reabsorption. / Mertz, J. I.; Haas, J. A.; Berndt, T. J.; Burnett, John C Jr.; Knox, F. G.

In: The American journal of physiology, Vol. 247, No. 1 Pt 2, 07.1984.

Research output: Contribution to journalArticle

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