Effects of body fat distribution on regional lipolysis in obesity

Mary L. Martin, Michael Dennis Jensen

Research output: Contribution to journalArticle

197 Citations (Scopus)

Abstract

To determine the contribution of the major body fat depots to systemic free fatty acid (FFA) availability, palmitate ((1-14C]-palmitate) release was measured from leg (lower body) and non-leg (upper body) fat in eight upper body obese (UB Ob), six lower body obese (LB Ob), and six nonobese (Non Ob) agematched premenopausal women in the overnight postabsorptive state. Splanchnic palmitate release was determined in 16 of these subjects. Results: total palmitate release was greater in UB Ob (P < 0.005) than LB Ob or Non Ob women (161±16 vs. 111±9 vs. 92±9 μmol/min, respectively). Despite increased leg fat mass in obese women, leg palmitate release was similar in each group. Therefore, leg fat palmitate release was greater in Non Ob women than LB Ob (P < 0.01) or UB Ob (P = 0.06) women (3.7±0.3 vs. 2.4+0.2 vs. 2.7+0.2 μmo;·kg fat-1 ·min-1, respectively). Upper body fat palmitate release was less (P < 0.01) in LB Ob than Non Ob or UB Ob women (3.0±0.4 vs. 5.0±0.3 vs. 4.9±0.4 μmol·kg far-1·min-1, respectively). Splanchnic palmitate release accounted for 20-32% of upper body fat palmitate release in each group (P = NS between groups). Leg fat palmitate release was significantly less than upper body fat palmitate release. We conclude that the major difference in resting FFA metabolism between UB Ob and LB Ob women is the ability of the later to down-regulate upper body fat lipolysis to maintain normal FFA availability.

Original languageEnglish (US)
Pages (from-to)609-613
Number of pages5
JournalJournal of Clinical Investigation
Volume88
Issue number2
StatePublished - Aug 1991

Fingerprint

Body Fat Distribution
Palmitates
Lipolysis
Obesity
Adipose Tissue
Leg
Fats
Nonesterified Fatty Acids
Viscera
Down-Regulation

Keywords

  • [1-C]palmitate
  • Body composition
  • Free fatty acid

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Effects of body fat distribution on regional lipolysis in obesity. / Martin, Mary L.; Jensen, Michael Dennis.

In: Journal of Clinical Investigation, Vol. 88, No. 2, 08.1991, p. 609-613.

Research output: Contribution to journalArticle

@article{8c24f27dee0b4d6abc3625ee858943e7,
title = "Effects of body fat distribution on regional lipolysis in obesity",
abstract = "To determine the contribution of the major body fat depots to systemic free fatty acid (FFA) availability, palmitate ((1-14C]-palmitate) release was measured from leg (lower body) and non-leg (upper body) fat in eight upper body obese (UB Ob), six lower body obese (LB Ob), and six nonobese (Non Ob) agematched premenopausal women in the overnight postabsorptive state. Splanchnic palmitate release was determined in 16 of these subjects. Results: total palmitate release was greater in UB Ob (P < 0.005) than LB Ob or Non Ob women (161±16 vs. 111±9 vs. 92±9 μmol/min, respectively). Despite increased leg fat mass in obese women, leg palmitate release was similar in each group. Therefore, leg fat palmitate release was greater in Non Ob women than LB Ob (P < 0.01) or UB Ob (P = 0.06) women (3.7±0.3 vs. 2.4+0.2 vs. 2.7+0.2 μmo;·kg fat-1 ·min-1, respectively). Upper body fat palmitate release was less (P < 0.01) in LB Ob than Non Ob or UB Ob women (3.0±0.4 vs. 5.0±0.3 vs. 4.9±0.4 μmol·kg far-1·min-1, respectively). Splanchnic palmitate release accounted for 20-32{\%} of upper body fat palmitate release in each group (P = NS between groups). Leg fat palmitate release was significantly less than upper body fat palmitate release. We conclude that the major difference in resting FFA metabolism between UB Ob and LB Ob women is the ability of the later to down-regulate upper body fat lipolysis to maintain normal FFA availability.",
keywords = "[1-C]palmitate, Body composition, Free fatty acid",
author = "Martin, {Mary L.} and Jensen, {Michael Dennis}",
year = "1991",
month = "8",
language = "English (US)",
volume = "88",
pages = "609--613",
journal = "Journal of Clinical Investigation",
issn = "0021-9738",
publisher = "The American Society for Clinical Investigation",
number = "2",

}

TY - JOUR

T1 - Effects of body fat distribution on regional lipolysis in obesity

AU - Martin, Mary L.

AU - Jensen, Michael Dennis

PY - 1991/8

Y1 - 1991/8

N2 - To determine the contribution of the major body fat depots to systemic free fatty acid (FFA) availability, palmitate ((1-14C]-palmitate) release was measured from leg (lower body) and non-leg (upper body) fat in eight upper body obese (UB Ob), six lower body obese (LB Ob), and six nonobese (Non Ob) agematched premenopausal women in the overnight postabsorptive state. Splanchnic palmitate release was determined in 16 of these subjects. Results: total palmitate release was greater in UB Ob (P < 0.005) than LB Ob or Non Ob women (161±16 vs. 111±9 vs. 92±9 μmol/min, respectively). Despite increased leg fat mass in obese women, leg palmitate release was similar in each group. Therefore, leg fat palmitate release was greater in Non Ob women than LB Ob (P < 0.01) or UB Ob (P = 0.06) women (3.7±0.3 vs. 2.4+0.2 vs. 2.7+0.2 μmo;·kg fat-1 ·min-1, respectively). Upper body fat palmitate release was less (P < 0.01) in LB Ob than Non Ob or UB Ob women (3.0±0.4 vs. 5.0±0.3 vs. 4.9±0.4 μmol·kg far-1·min-1, respectively). Splanchnic palmitate release accounted for 20-32% of upper body fat palmitate release in each group (P = NS between groups). Leg fat palmitate release was significantly less than upper body fat palmitate release. We conclude that the major difference in resting FFA metabolism between UB Ob and LB Ob women is the ability of the later to down-regulate upper body fat lipolysis to maintain normal FFA availability.

AB - To determine the contribution of the major body fat depots to systemic free fatty acid (FFA) availability, palmitate ((1-14C]-palmitate) release was measured from leg (lower body) and non-leg (upper body) fat in eight upper body obese (UB Ob), six lower body obese (LB Ob), and six nonobese (Non Ob) agematched premenopausal women in the overnight postabsorptive state. Splanchnic palmitate release was determined in 16 of these subjects. Results: total palmitate release was greater in UB Ob (P < 0.005) than LB Ob or Non Ob women (161±16 vs. 111±9 vs. 92±9 μmol/min, respectively). Despite increased leg fat mass in obese women, leg palmitate release was similar in each group. Therefore, leg fat palmitate release was greater in Non Ob women than LB Ob (P < 0.01) or UB Ob (P = 0.06) women (3.7±0.3 vs. 2.4+0.2 vs. 2.7+0.2 μmo;·kg fat-1 ·min-1, respectively). Upper body fat palmitate release was less (P < 0.01) in LB Ob than Non Ob or UB Ob women (3.0±0.4 vs. 5.0±0.3 vs. 4.9±0.4 μmol·kg far-1·min-1, respectively). Splanchnic palmitate release accounted for 20-32% of upper body fat palmitate release in each group (P = NS between groups). Leg fat palmitate release was significantly less than upper body fat palmitate release. We conclude that the major difference in resting FFA metabolism between UB Ob and LB Ob women is the ability of the later to down-regulate upper body fat lipolysis to maintain normal FFA availability.

KW - [1-C]palmitate

KW - Body composition

KW - Free fatty acid

UR - http://www.scopus.com/inward/record.url?scp=0025771285&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025771285&partnerID=8YFLogxK

M3 - Article

C2 - 1864970

AN - SCOPUS:0025771285

VL - 88

SP - 609

EP - 613

JO - Journal of Clinical Investigation

JF - Journal of Clinical Investigation

SN - 0021-9738

IS - 2

ER -