Effects of augmented respiratory muscle pressure production on locomotor limb venous return during calf contraction exercise

Jordan D Miller, David F. Pegelow, Anthony J. Jacques, Jerome A. Dempsey

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

We determined effects of augmented inspiratory and expiratory intrathoracic pressure or abdominal pressure (Pab) excursions on within-breath changes in steady-state femoral venous blood flow (Q̇ fv) and net Q̇ fv during tightly controlled (total breath time = 4 s, duty cycle = 0.5) accessory muscle/"rib cage" (ΔPab <2 cmH 2O) or diaphragmatic (ΔPab >5 cmH 2O) breathing. Selectively augmenting inspiratory intrathoracic pressure excursion during rib cage breathing augmented inspiratory facilitation of Q̇ fv from the resting limb (69% and 89% of all flow occurred during nonloaded and loaded inspiration, respectively); however, net Q̇ fv in the steady state was not altered because of slight reductions in femoral venous return during the ensuing expiratory phase of the breath. Selectively augmenting inspiratory esophageal pressure excursion during a predominantly diaphragmatic breath at rest did not alter within-breath changes in Q̇ fV relative to nonloaded conditions (net retrograde flow = -9 ± 12% and -4 ± 9% during nonloaded and loaded inspiration, respectively), supporting the notion that the inferior vena cava is completely collapsed by relatively small increases in gastric pressure. Addition of inspiratory + expiratory loading to diaphragmatic breathing at rest resulted in reversal of within-breath changes in Q̇ fv, such that >90% of all anterograde Q̇ fv occurred during inspiration. Inspiratory + expiratory loading also reduced steady-state Q̇ fv during mild- and moderate-intensity calf contractions compared with inspiratory loading alone. We conclude that 1) exaggerated inspiratory pressure excursions may augment within-breath changes in femoral venous return but do not increase net Q̇ fv in the steady state and 2) active expiration during diaphragmatic breathing reduces the steady-state hyperemic response to dynamic exercise by mechanically impeding venous return from the locomotor limb, which may contribute to exercise limitation in health and disease.

Original languageEnglish (US)
Pages (from-to)1802-1815
Number of pages14
JournalJournal of Applied Physiology
Volume99
Issue number5
DOIs
StatePublished - Nov 2005
Externally publishedYes

Fingerprint

Respiratory Muscles
Extremities
Pressure
Respiration
Thigh
Inferior Vena Cava
Stomach
Muscles
Health

Keywords

  • Blood flow
  • Breathing mechanics
  • Expiratory flow limitation
  • Starling resistor

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Effects of augmented respiratory muscle pressure production on locomotor limb venous return during calf contraction exercise. / Miller, Jordan D; Pegelow, David F.; Jacques, Anthony J.; Dempsey, Jerome A.

In: Journal of Applied Physiology, Vol. 99, No. 5, 11.2005, p. 1802-1815.

Research output: Contribution to journalArticle

Miller, Jordan D ; Pegelow, David F. ; Jacques, Anthony J. ; Dempsey, Jerome A. / Effects of augmented respiratory muscle pressure production on locomotor limb venous return during calf contraction exercise. In: Journal of Applied Physiology. 2005 ; Vol. 99, No. 5. pp. 1802-1815.
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